Guo Jun, Gao Feng, Zhang Feng, Zhao Xinmin, Zhao Ruoyang
Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China.
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.
JACS Au. 2025 Aug 18;5(9):4134-4154. doi: 10.1021/jacsau.5c00669. eCollection 2025 Sep 22.
This perspective articulates the transformative role of biomineralization in materials science and biomedical engineering. Establishing fundamental principles through systematic analysis of mineralization categories, dynamic processes, and crystal nucleation/growth mechanisms, the review progresses to contemporary bioinspired applicationsfrom biotemplated nanocarriers for targeted drug delivery to precision tooth remineralization and engineered bone scaffolds. Critical examination of persistent challenges (morphological precision, scalable production, biological template design) precedes discussion of emerging technological vectors: superhydrophilic/hydrophobic interfacial engineering and hybrid composite systems. The discourse extends to diagnostic biosensing platforms and AI-optimized mineralization architectures as frontier applications. Conclusively, the work frames an interdisciplinary convergence of biological, chemical, and engineering paradigms essential for realizing biomineralization's potential while mapping strategic research directions.
本文阐述了生物矿化在材料科学和生物医学工程中的变革性作用。通过对矿化类别、动态过程以及晶体成核/生长机制的系统分析建立基本原理，该综述进而探讨了当代受生物启发的应用——从用于靶向药物递送的生物模板纳米载体到精确的牙齿再矿化和工程化骨支架。在讨论新兴技术方向（超亲水/疏水界面工程和混合复合系统）之前，先对持续存在的挑战（形态精度、可扩展生产、生物模板设计）进行了批判性审视。论述还扩展到了诊断生物传感平台和人工智能优化的矿化结构等前沿应用。最后，这项工作构建了生物、化学和工程范式的跨学科融合，这对于实现生物矿化的潜力至关重要，同时还规划了战略研究方向。
