Hamed Mohamed, Abdel-Wahab Mohammed, Said Rashad E M, Sayed Alaa El-Din H
Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Skip Bertman Drive, Baton Rouge, LA 70803, USA.
Department of Zoology, Faculty of Science, Al-Azhar University (Assiut Branch), Assiut 71524, Egypt.
Int J Mol Sci. 2025 Sep 12;26(18):8898. doi: 10.3390/ijms26188898.
Perfluorooctane sulfonate (PFOS), which is known for its environmental persistence and bioaccumulation, poses substantial impacts to aquatic ecosystems. This study assesses the toxic effects of PFOS in the freshwater snail using biomarkers for antioxidant activity, neurotoxicity, and tissue damage. Snails exposed to PFOS (1, 3, 10 mg/L for 14 days) displayed lipid peroxidation (LPO) levels that increased by 16.3-67.5%, and malondialdehyde (MDA) levels that rose by 10.0-58.4%, indicating oxidative damage. Enzyme activities for glutathione S-transferase (GST), glutathione peroxidase (GPx), and catalase (CAT) increased, ranging from 10.0 to 58.3%, 10.0 to 58.4%, and 10.0 to 58.4%, respectively, whereas levels of reduced glutathione (GSH) dropped by 15.0-41.5% and Superoxide dismutase (SOD) decreased by 15.0-41.4%. The activity of acetylcholinesterase (AchE) was reduced by a range of 15.0-40.0%, suggesting neurotoxic effects. Histopathological changes in the digestive gland were also noted. Further research on the effects of PFOS on mollusks is required, and investigation into sex-specific toxicity is needed. This shed light on as a sentinel species, providing helpful information for the monitoring and regulation of PFOS in aquatic environments.
全氟辛烷磺酸（PFOS）以其环境持久性和生物累积性而闻名，对水生生态系统造成重大影响。本研究使用抗氧化活性、神经毒性和组织损伤的生物标志物评估了PFOS对淡水蜗牛的毒性作用。暴露于PFOS（1、3、10mg/L，持续14天）的蜗牛表现出脂质过氧化（LPO）水平增加了16.3 - 67.5%，丙二醛（MDA）水平上升了10.0 - 58.4%，表明存在氧化损伤。谷胱甘肽S - 转移酶（GST）、谷胱甘肽过氧化物酶（GPx）和过氧化氢酶（CAT）的酶活性分别增加了10.0%至58.3%、10.0%至58.4%和10.0%至58.4%，而还原型谷胱甘肽（GSH）水平下降了15.0 - 41.5%，超氧化物歧化酶（SOD）下降了15.0 - 41.4%。乙酰胆碱酯酶（AchE）的活性降低了15.0 - 40.0%，表明存在神经毒性作用。还注意到消化腺的组织病理学变化。需要进一步研究PFOS对软体动物的影响，并调查性别特异性毒性。这为将蜗牛作为哨兵物种提供了线索，为水生环境中PFOS的监测和监管提供了有用信息。
