口服孕激素避孕期间的血液凝固与血小板聚集：一项随访研究。
Blood clotting and platelet aggregation during oral progestogen contraception: a follow-up study.
作者信息
Poller L, Thomson J M, Thomas W, Wray C
出版信息
Br Med J. 1971 Mar 27;1(5751):705-7. doi: 10.1136/bmj.1.5751.705.
A two-year follow-up study of progestogen-only contraception with chlormadinone acetate indicates no increase of the level of factors VII and X, as found after three cycles with all oestrogen-progestogen oral contraceptives. Clotting factors which were raised with combined preparations became normal after the sixth monthly cycle of progestogen and remained normal during the two-year period of study.From 12 months onwards significant changes in the thromboelastograph pattern were recorded, but not to the same extent as with combined preparations. At two years platelet aggregation was significantly accelerated with chlormadinone acetate but was not as rapid as with combined preparations.
一项对醋酸氯地孕酮单纯孕激素避孕法的两年随访研究表明，与使用所有雌激素-孕激素口服避孕药三个周期后所发现的情况不同，该方法并未使凝血因子VII和X水平升高。在联合制剂中升高的凝血因子在使用孕激素的第六个月经周期后恢复正常，并在两年的研究期间保持正常。从12个月起，记录到血栓弹力图模式有显著变化，但程度不如联合制剂。在两年时，醋酸氯地孕酮使血小板聚集显著加速，但不如联合制剂那么迅速。
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