免疫反应的胸腺依赖性：小鼠对半抗原决定簇NIP的反应。
Thymus dependence of the immune response: response to the haptenic determinant NIP in mice.
作者信息
Aird J
出版信息
Immunology. 1971 Apr;20(4):617-24.
Normal, deprived (thymectomized, irradiated) and reconstituted (thymectomized, irradiated, thymus grafted) CBA mice were immunized with either a polyvalent or a mainly monovalent conjugate of the hapten 3-iodo-4-hydroxy-5-nitrophenylacetic acid and bovine serum albumin. The humoral antibody response to the hapten was determined by the phage inactivation technique. The response of deprived mice was always significantly lower than the response of either normal or reconstituted animals. However, by increasing the dose of antigen in these mice it was possible to elicit some degree of responsiveness, but only in those groups which had received the polyvalent conjugate.
正常、去胸腺（胸腺切除、照射）和重建（胸腺切除、照射、胸腺移植）的CBA小鼠用半抗原3-碘-4-羟基-5-硝基苯乙酸与牛血清白蛋白的多价或主要单价缀合物进行免疫。通过噬菌体灭活技术测定对半抗原的体液抗体反应。去胸腺小鼠的反应总是明显低于正常或重建动物的反应。然而，通过增加这些小鼠的抗原剂量，可以引发一定程度的反应性，但仅在接受多价缀合物的那些组中。
Zotero 插件