Daoulas-Le Bourdelles F, Berche P, Véron M
Ann Microbiol (Paris). 1977 Jul;128B(1):61-71.
The protective antibodies obtained in mice with an acellular vaccine P2 from Pseudomonas aeruginosa have been titered in vivo by a bacterial clearance technique. The kinetics of the bacterial disappearance from the circulating blood were compared in mice which had been vaccinated or had received injection of specific serum, and in normal mice. The following results were obtained; (a) the disappearance of the bacteria from the blood is quicker in immunized animals; (b) the rate of bacteria in the blood depends on doses of injected serum; (c) the titers of protective antibodies expressed by 99% clearance dose is directly in relation with the vaccinating dose.
利用细菌清除技术在体内测定了用铜绿假单胞菌无细胞疫苗P2免疫的小鼠所获得的保护性抗体效价。比较了接种疫苗或注射特异性血清的小鼠以及正常小鼠血液中细菌消失的动力学情况。获得了以下结果：(a) 在免疫动物中，细菌从血液中的消失更快；(b) 血液中的细菌数量取决于注射血清的剂量；(c) 以99%清除剂量表示的保护性抗体效价与疫苗接种剂量直接相关。
