针对假单胞菌核糖体疫苗的多价抗血清：保护小鼠抵御临床分离菌株
Polyvalent antisera to Pseudomonas ribosomal vaccines: protection of mice against clinically isolated strains.
作者信息
Lieberman M M, Wright G L, Wolcott K M, McKissock-Desoto D C
出版信息
Infect Immun. 1980 Aug;29(2):489-93. doi: 10.1128/iai.29.2.489-493.1980.
Abstract
The preparation of polyvalent antisera to ribosomal vaccines from Pseudomonas aeruginosa is described. The ability of these antisera to protect mice by passive immunization against challenge with randomly chosen, clinically isolated strains of P. aeruginosa is reported. Significant protection was achieved against 34 of 40 strains tested (85%). Included among these strains against which protection was achieved were four mucoid strains. In addition, the degree of cross-protection attainable by the ribosomal vaccines was investigated. The results obtained indicated that these vaccines are generally serotype specific.
摘要
本文描述了铜绿假单胞菌核糖体疫苗多价抗血清的制备方法。报告了这些抗血清通过被动免疫保护小鼠免受随机选择的临床分离铜绿假单胞菌菌株攻击的能力。在测试的40株菌株中，对34株（85%）实现了显著保护。实现保护的菌株中包括4株黏液型菌株。此外，还研究了核糖体疫苗可达到的交叉保护程度。所得结果表明，这些疫苗通常具有血清型特异性。
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