Alger Bradley E
Department of Pharmacology and Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Hippocampus. 2025 Nov;35(6):e70047. doi: 10.1002/hipo.70047.
This essay describes the development of the in vitro hippocampal slice technique and my small contributions to it and to influencing Roger Nicoll's early interests in the hippocampus and LTP. My Ph.D. work at Harvard with Timothy Teyler was on field potential studies of synaptic plasticity, including LTP, in the rat in vitro hippocampal slice. As a postdoc, I introduced the slice preparation to Roger Nicoll's lab at UCSF but failed to interest him in LTP. Here I explain how Nicoll's scientific philosophy both motivated me to develop our first submersion slice chamber and kept him from investigating LTP for nearly a decade. Finally, I recount the history of the name "LTP."
本文描述了体外海马切片技术的发展以及我对该技术所做的微小贡献，还有我对影响罗杰·尼科尔早期对海马体和长时程增强（LTP）的兴趣所起的作用。我在哈佛与蒂莫西·泰勒攻读博士学位期间，从事的是大鼠体外海马切片中包括长时程增强在内的突触可塑性的场电位研究。作为博士后，我将切片制备方法引入了加州大学旧金山分校罗杰·尼科尔的实验室，但未能引起他对长时程增强的兴趣。在此我解释一下尼科尔的科学理念是如何既促使我开发出我们的第一个浸没式切片槽，又使他在近十年的时间里没有对长时程增强展开研究的。最后，我讲述了“长时程增强”这个名称的由来。
