Cruz-Lugo Angela, Rivera-Santiago Sofía V, Cortés-Norat Ana S, Rosario-Isona Valeria I, Nieves-Moron Sandra V, Viera-Sánchez Victoria V, Díaz-Vázquez Liz M
University of Puerto Rico, Río Piedras Campus, San Juan 00925-2537, Puerto Rico.
ACS Omega. 2025 Oct 25;10(43):52018-52031. doi: 10.1021/acsomega.5c09406. eCollection 2025 Nov 4.
The development of sustainable skincare formulations is increasingly important due to growing customer demand for eco-friendly and health-conscious products. Conventional formulations often rely on synthetic ingredients that can harm human health and marine ecosystems, underscoring the need for natural and biodegradable alternatives. Recurrent blooms in tropical regions generate vast, underutilized biomass, posing environmental and economic challenges, such as habitat disruption and waste accumulation. Valorizing this biomass for nanocarrier production aligns with circular economic principles and promotes marine resource utilization. This study developed and characterized fucoidan-coated liposomes as nanocarriers for skincare applications through comprehensive physicochemical and functional evaluations. Lipids extracted from were combined with fucoidan, a sulfated polysaccharide, using the thin-film hydration technique in a 1:1 v/v ratio. Treatments included empty and fucoidan-coated liposomes, assessed for particle size, zeta potential, thermal stability, photodegradation resilience, and antioxidant activity. Fucoidan-coated liposomes exhibited a particle size of 673 ± 10 nm, a PDI of 0.8, and a zeta potential of -72 mV, maintaining colloidal stability for 28 days. FTIR confirmed structural integrity under simulated sunlight, while TGA, DSC, and gas chromatography showed improved lipid retention and thermal stability. Although empty liposomes exhibited stronger initial radical scavenging activity (0.9 ± 0.4 g/L), fucoidan-coated liposomes (2.0 ± 0.6 g/L) provided more sustained antioxidant effects due to the protective polysaccharide layer. This approach integrates marine biomass valorization with enhanced liposomal stability and antioxidant performance, positioning fucoidan-coated liposomes as a robust and eco-friendly platform for next-generation skincare formulations within a circular economy framework.
由于客户对环保和注重健康产品的需求不断增长，可持续护肤品配方的开发变得越来越重要。传统配方通常依赖合成成分，这些成分可能会损害人类健康和海洋生态系统，这凸显了对天然和可生物降解替代品的需求。热带地区反复出现的藻华产生了大量未充分利用的生物质，带来了环境和经济挑战，如栖息地破坏和废物积累。将这种生物质用于纳米载体生产符合循环经济原则，并促进海洋资源的利用。本研究通过全面的物理化学和功能评估，开发并表征了岩藻依聚糖包被的脂质体作为护肤品应用的纳米载体。使用薄膜水化技术，将从[未提及来源]提取的脂质与岩藻依聚糖（一种硫酸化多糖）以1:1 v/v的比例混合。处理包括空脂质体和岩藻依聚糖包被的脂质体，评估其粒径、zeta电位、热稳定性、光降解抗性和抗氧化活性。岩藻依聚糖包被的脂质体粒径为673±10 nm，多分散指数（PDI）为0.8，zeta电位为-72 mV，在28天内保持胶体稳定性。傅里叶变换红外光谱（FTIR）证实在模拟阳光下结构完整，而热重分析（TGA）、差示扫描量热法（DSC）和气相色谱显示脂质保留和热稳定性得到改善。尽管空脂质体表现出更强的初始自由基清除活性（0.9±0.4 g/L），但由于保护性多糖层，岩藻依聚糖包被的脂质体（2.0±0.6 g/L）提供了更持久的抗氧化效果。这种方法将海洋生物质的增值与增强的脂质体稳定性和抗氧化性能相结合，将岩藻依聚糖包被的脂质体定位为循环经济框架内下一代护肤品配方的强大且环保的平台。
