前列腺素合成酶的内源性抑制剂
Endogenous inhibitor of prostaglandin synthetase.
作者信息
Saeed S A, McDonald-Gibson W J, Cuthbert J, Copas J L, Schneider C, Gardiner P J, Butt N M, Collier H O
出版信息
Nature. 1977 Nov 3;270(5632):32-6. doi: 10.1038/270032a0.
DOI:10.1038/270032a0
PMID:412109
Abstract
Mammalian serum and plasma contain an endogenous inhibitor of prostaglandin synthetase (EIPS). Human plasma fractions rich in EIPS show anti-inflammatory activity in vivo. In rats, glucocorticoids raise EIPS activity of plasma and serum. These findings suggest the existence of a natural mechanism of controlling prostaglandin synthesis, possibly related to corticosteroid action.
摘要
哺乳动物的血清和血浆含有前列腺素合成酶的内源性抑制剂（EIPS）。富含EIPS的人血浆组分在体内显示出抗炎活性。在大鼠中，糖皮质激素可提高血浆和血清的EIPS活性。这些发现提示存在一种控制前列腺素合成的天然机制，可能与皮质类固醇作用有关。
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