不同α-基因座同种异型兔免疫球蛋白A重链的序列研究。
Sequence studies on the heavy chain of rabbit immunoglobulin A of different alpha-locus allotypes.
作者信息
Johnstone A P, Mole L E
出版信息
Biochem J. 1977 Oct 1;167(1):255-67. doi: 10.1042/bj1670255.
The amino acid sequence was determined of part of the variable region of heavy chain from rabbit immunoglobulin A of allotypes a1 and a3. Two corrections of the primary sequence of Aa1 gamma-chains are reported; most of the structural correlates of the alpha-locus allotypes are confirmed. The amino acid sequence of the N-terminal 20 residues of alpha-negative molecules was also determined and found to be homologous to the human VhIII subgroup. These molecules are present in a much higher proportion in the alpha-chain pool than in the gamma-chain.
测定了同种异型a1和a3的兔免疫球蛋白A重链可变区部分的氨基酸序列。报告了Aa1γ链一级序列的两处校正；α基因座同种异型的大多数结构关联得到证实。还测定了α阴性分子N端20个残基的氨基酸序列，发现其与人类VhIII亚组同源。这些分子在α链库中的比例远高于γ链。
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