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兔免疫球蛋白重链可变区中的一个遗传标记。

A genetic marker in the variable region of rabbit immunoglobulin heavy chain.

作者信息

Mole L R

出版信息

Biochem J. 1975 Nov;151(2):351-9. doi: 10.1042/bj1510351.

DOI:10.1042/bj1510351
PMID:814893
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1172365/
Abstract

A previous study [Mole et al. (1971) Biochem. J. 124, 301-318] showed several differences in sequence between the variable (V) regions of rabbit immunoglobulin Aa1 and Aa3 heavy chains. The inheritance of one such difference has been followed in a family of 38 rabbits by a radioautographic peptide-'map' technique and is shown to segregate in a Mendelian fashion. This clearly demonstrates the presence of a genetic marker in the rabbit heavy-chain V region, although the finding that Aa2 and Aa3 heavy chains have identity of sequence in the region studied obscures the relationship of this genetic marker to the a locus.

摘要

先前的一项研究[莫尔等人（1971年），《生物化学杂志》124卷，301 - 318页]表明，兔免疫球蛋白Aa1和Aa3重链可变（V）区之间在序列上存在若干差异。通过放射自显影肽“图谱”技术，在一个由38只兔子组成的家系中追踪了其中一种差异的遗传情况，结果显示其以孟德尔方式分离。这清楚地证明了兔重链V区存在一个遗传标记，尽管在所研究区域中Aa2和Aa3重链具有相同序列这一发现使该遗传标记与α基因座的关系变得模糊。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1d3/1172365/0cc2f0befcac/biochemj00548-0171-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1d3/1172365/f80cbdd36189/biochemj00548-0167-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1d3/1172365/c6bca9cbe265/biochemj00548-0168-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1d3/1172365/8ebb3574f6bc/biochemj00548-0169-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1d3/1172365/899db3eb0148/biochemj00548-0170-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1d3/1172365/0cc2f0befcac/biochemj00548-0171-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1d3/1172365/f80cbdd36189/biochemj00548-0167-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1d3/1172365/c6bca9cbe265/biochemj00548-0168-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1d3/1172365/8ebb3574f6bc/biochemj00548-0169-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1d3/1172365/899db3eb0148/biochemj00548-0170-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1d3/1172365/0cc2f0befcac/biochemj00548-0171-a.jpg

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本文引用的文献

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Depletion of glycogen synthetase and increase of glucose 6-phosphate dehydrogenase in livers of ethionine-treated mice.乙硫氨酸处理的小鼠肝脏中糖原合成酶的耗竭及葡萄糖-6-磷酸脱氢酶的增加。
Biochem J. 1965 Oct;97(1):32-6. doi: 10.1042/bj0970032.
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Allotype-related sequence variation of the heavy chain of rabbit immunoglobulin G.兔免疫球蛋白 G 重链同种异型相关序列变异。
Biochem J. 1968 May;107(6):753-63. doi: 10.1042/bj1070753.
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Allotypy of rabbit serum proteins. I. Immuno-chemical analysis leading to the individualization of seven main allotypes.
Distinct forms of both alpha and beta subunits are present in the human Ia molecular pool.
人类Ia分子库中存在α和β亚基的不同形式。
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4549-51. doi: 10.1073/pnas.78.7.4549.
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Analysis of HLA-DR polymorphism by two-dimensional peptide mapping.通过二维肽图谱分析HLA-DR多态性。
Proc Natl Acad Sci U S A. 1981 Jan;78(1):534-8. doi: 10.1073/pnas.78.1.534.
5
Sequence studies on the constant region of the Fd sections of rabbit immunoglobulin G of different allotype.不同同种异型兔免疫球蛋白G的Fd片段恒定区的序列研究。
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6
Sequence studies on the heavy chain of rabbit immunoglobulin A of different alpha-locus allotypes.不同α-基因座同种异型兔免疫球蛋白A重链的序列研究。
Biochem J. 1977 Oct 1;167(1):255-67. doi: 10.1042/bj1670255.
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J Exp Med. 1960 Jul 1;112(1):107-24. doi: 10.1084/jem.112.1.107.
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Nature. 1966 Aug 6;211(5049):591-3. doi: 10.1038/211591a0.
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