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组织相容性不相容的T淋巴细胞与B淋巴细胞之间的细胞相互作用。H-2基因复合体决定淋巴细胞间成功的生理相互作用。

Cell interactions between histoincompatible T and B lymphocytes. The H-2 gene complex determines successful physiologic lymphocyte interactions.

作者信息

Katz D H, Hamaoka T, Dorf M E, Benacerraf B

出版信息

Proc Natl Acad Sci U S A. 1973 Sep;70(9):2624-8. doi: 10.1073/pnas.70.9.2624.

DOI:10.1073/pnas.70.9.2624
PMID:4126264
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC427069/
Abstract

We used congenic-resistant mouse strains to answer questions concerning the respective roles of genes coding for major histocompatibility and background genotypes in T (thymus-derived)-B (bone marrow-derived) lymphocyte cooperative responses to hapten-protein conjugates. These studies demonstrate conclusively that the gene or genes present in the H-2 complex control the capacity of antigen-specific T and B cells to effectively interact. These findings led us to postulate that there exists on the B-lymphocyte surface an "acceptor" molecule for the active T-cell product or for the T cell itself.

摘要

我们使用同类系抗性小鼠品系来回答有关主要组织相容性编码基因和背景基因型在T（胸腺衍生）-B（骨髓衍生）淋巴细胞对半抗原-蛋白质缀合物的协同反应中各自作用的问题。这些研究确凿地证明，H-2复合体中存在的一个或多个基因控制着抗原特异性T细胞和B细胞有效相互作用的能力。这些发现使我们推测，B淋巴细胞表面存在一种针对活性T细胞产物或T细胞本身的“受体”分子。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f6d/427069/d2a4a12c724f/pnas00136-0162-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f6d/427069/d2a4a12c724f/pnas00136-0162-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f6d/427069/d2a4a12c724f/pnas00136-0162-a.jpg

相似文献

1
Cell interactions between histoincompatible T and B lymphocytes. The H-2 gene complex determines successful physiologic lymphocyte interactions.组织相容性不相容的T淋巴细胞与B淋巴细胞之间的细胞相互作用。H-2基因复合体决定淋巴细胞间成功的生理相互作用。
Proc Natl Acad Sci U S A. 1973 Sep;70(9):2624-8. doi: 10.1073/pnas.70.9.2624.
2
Cell interactions between histoincompatible T and B lymphocytes. II. Failure of physiologic cooperative interactions between T and B lymphocytes from allogeneic donor strains in humoral response to hapten-protein conjugates.组织相容性不相容的T淋巴细胞和B淋巴细胞之间的细胞相互作用。II. 来自同种异体供体品系的T淋巴细胞和B淋巴细胞在对半抗原-蛋白质结合物的体液反应中缺乏生理性协同相互作用。
J Exp Med. 1973 Jun 1;137(6):1405-18. doi: 10.1084/jem.137.6.1405.
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Critical role of determinant presentation in the induction of specific responses in immunocompetent lymphocytes.决定簇呈现在免疫活性淋巴细胞特异性反应诱导中的关键作用。
J Exp Med. 1973 Apr 1;137(4):967-90. doi: 10.1084/jem.137.4.967.
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Cell interactions between histoincompatible T and B lymphocytes. V. Failure of histoincompatible T cells to interfere with physiologic cooperation between syngeneic T and B lymphocytes.组织相容性不相容的T淋巴细胞与B淋巴细胞之间的细胞相互作用。V. 组织相容性不相容的T细胞无法干扰同基因T淋巴细胞与B淋巴细胞之间的生理协同作用。
J Immunol. 1974 Feb;112(2):855-7.
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Immunogenicity of macrophage-bound antigens: the requirement for hapten and carrier determinants to be on the same molecule for T and B lymphocyte collaboration.巨噬细胞结合抗原的免疫原性：T 细胞和 B 淋巴细胞协作时半抗原和载体决定簇位于同一分子上的必要性。
Eur J Immunol. 1973 Sep;3(9):559-63. doi: 10.1002/eji.1830030907.
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Macrophages bearing hapten-carrier molecules as foci inducers for T and B lymphocyte interaction.带有半抗原载体分子的巨噬细胞作为T和B淋巴细胞相互作用的灶性诱导物。
Eur J Immunol. 1974 Jan;4(1):1-4. doi: 10.1002/eji.1830040102.
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Hapten-specific IgE antibody responses in mice. I. Secondary IgE responses in irradiated recipients of syngeneic primed spleen cells.小鼠对半抗原特异性的IgE抗体反应。I. 同基因致敏脾细胞照射受体中的二次IgE反应。
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Cell interactions between histoincompatible T and B lymphocytes. VIII. In vivo cooperative responses between lymphocytes are controlled by genes in the K-end of the H-2 complex.
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Cell interactions between histoincompatible T and B lymphocytes. VII. Cooperative responses between lymphocytes are controlled by genes in the I region of the H-2 complex.组织相容性不相容的T淋巴细胞和B淋巴细胞之间的细胞相互作用。VII.淋巴细胞之间的协同反应受H-2复合体I区基因的控制。
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Hapten-specific IgE antibody responses in mice. 3. Establishment of parameters for generation of helper T cell function regulating the primary and secondary responses of IgE and IgG B lymphocytes.小鼠对半抗原特异性的IgE抗体反应。3. 调节IgE和IgG B淋巴细胞初次和二次反应的辅助性T细胞功能产生参数的确定。
J Immunol. 1974 Sep;113(3):958-73.

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Immunological specificity of delayed and immediate hypersensitivity reactions.迟发型和速发型超敏反应的免疫特异性
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T lymphocytes responding to Mls-locus antigens are Lyt-1+, 2- and I-A restricted.对 Mls 基因座抗原发生反应的 T 淋巴细胞为 Lyt-1+、2-和 I-A 限制。
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胸腺细胞与骨髓细胞之间的免疫互补——免疫活性双细胞理论的一个模型。
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Cell interactions between histoincompatible T and B lymphocytes. I. Allogeneic effect by irradiated host T cells on adoptively transferred histoincompatible B lymphocytes.组织相容性不相容的T淋巴细胞与B淋巴细胞之间的细胞相互作用。I. 受照射宿主T细胞对过继转移的组织相容性不相容B淋巴细胞的同种异体效应。
J Exp Med. 1973 Jun 1;137(6):1393-404. doi: 10.1084/jem.137.6.1393.
6
Radioresistance of carrier-specific helper thymus-derived lymphocytes in mice.小鼠中载体特异性辅助性胸腺来源淋巴细胞的辐射抗性
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H-2 dependence of co-operation between T and B cells in vivo.体内T细胞与B细胞合作的H-2依赖性
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8
The allogeneic effect on immune responses: model for regulatory influences of T lymphocytes on the immune system.同种异体对免疫反应的影响：T淋巴细胞对免疫系统调节作用的模型
Transplant Rev. 1972;12:141-79. doi: 10.1111/j.1600-065x.1972.tb00055.x.
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The allogeneic effect in inbred mice. II. Establishment of the cellular interactions required for enhancement of antibody production by the graft-versus-host reaction.近交系小鼠中的同种异体效应。II. 建立移植物抗宿主反应增强抗体产生所需的细胞相互作用。
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