Hamaoka T, Katz D H, Benacerraf B
Proc Natl Acad Sci U S A. 1972 Nov;69(11):3453-8. doi: 10.1073/pnas.69.11.3453.
The effect of x-irradiation on the capacity of carrier-specific mouse T (thymus-derived) lymphocytes to exert a helper function for hapten-specific B (bone marrow-derived) lymphocytes in vivo has been investigated again. Helper function is abolished by exposure of such cells to x-irradiation before, or immediately after, transfer to adoptive hosts. On the other hand, when exposure to x-irradiation occurs under circumstances in which the carrier-primed cells are well-localized in the appropriate lymphoid organs, i.e., either in the carrier-primed animal or 24 hr after adoptive transfer to syngeneic recipients, the capacity of T lymphocytes to serve as specific helper cells is clearly radioresistant. Evidence indicates that x-irradiation results in undefined, and subtle, changes in the migratory capacity of mouse T lymphocytes, but not in abrogation of T-cell helper function.
再次研究了X射线照射对载体特异性小鼠T（胸腺来源）淋巴细胞在体内对半抗原特异性B（骨髓来源）淋巴细胞发挥辅助功能能力的影响。在将此类细胞转移至受体宿主之前或之后立即进行X射线照射，会消除其辅助功能。另一方面，当在载体致敏细胞很好地定位于适当淋巴器官的情况下进行X射线照射时，即在载体致敏动物中或在同基因受体中进行过继转移24小时后，T淋巴细胞作为特异性辅助细胞的能力显然具有放射抗性。有证据表明，X射线照射会导致小鼠T淋巴细胞迁移能力发生不明确且细微的变化，但不会消除T细胞辅助功能。
