处于指数生长期和稳定生长期的细胞对博来霉素和1,3-双(2-氯乙基)-1-亚硝基脲的敏感性。
The sensitivity of cells in exponential and stationary phases of growth to bleomycin and to 1,3-bis(2-chloroethyl)-1-nitrosourea.
作者信息
Twentyman P R, Bleehen N M
出版信息
Br J Cancer. 1973 Dec;28(6):500-7. doi: 10.1038/bjc.1973.179.
Abstract
Studies of EMT6 mouse tumour cells growing in vitro have shown that these cells become less sensitive to bleomycin as they pass from exponential growth into stationary phase. This result is the opposite of that recently reported by two other groups of workers using different cell systems, but in agreement with the results of a third group of workers. Results for 1,3-bis(2-chloroethyl)-1-nitrosourea, however, confirm the findings of other workers that cells become more sensitive to this agent as they pass into stationary phase.These findings are discussed with particular reference to discrepancies which appear to exist between various cell systems.
摘要
对体外生长的EMT6小鼠肿瘤细胞的研究表明，当这些细胞从指数生长期进入静止期时，它们对博来霉素的敏感性会降低。这一结果与另外两组使用不同细胞系统的研究人员最近报道的结果相反，但与第三组研究人员的结果一致。然而，1,3-双（2-氯乙基）-1-亚硝基脲的结果证实了其他研究人员的发现，即细胞进入静止期时对该药物更敏感。本文特别参考了不同细胞系统之间似乎存在的差异对这些发现进行了讨论。
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