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多发性硬化症及其他神经系统疾病中淋巴细胞对脑碱性蛋白的致敏作用。

Lymphocyte sensitization to basic protein of brain in multiple sclerosis and other neurological diseases.

作者信息

Caspary E A, Field E J

出版信息

J Neurol Neurosurg Psychiatry. 1974 Jun;37(6):701-3. doi: 10.1136/jnnp.37.6.701.

DOI:10.1136/jnnp.37.6.701
PMID:4135820
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC494749/
Abstract

The number of lymphocytes in the blood sensitized to encephalitogenic factor (EF) is less in multiple sclerosis than it is in general paralysis of the insane. The number appears related to the extent of parenchymatous destruction. The study offers no support for the view that lymphocyte sensitization to EF is of pathogenetic significance in multiple sclerosis.

摘要

在多发性硬化症中，血液中对致脑炎因子（EF）致敏的淋巴细胞数量比在精神错乱性全身麻痹中要少。该数量似乎与实质破坏的程度有关。这项研究并不支持淋巴细胞对EF的致敏在多发性硬化症中具有致病意义这一观点。

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Lymphocyte sensitization to basic protein of brain in multiple sclerosis and other neurological diseases.多发性硬化症及其他神经系统疾病中淋巴细胞对脑碱性蛋白的致敏作用。
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本文引用的文献

1
AN ENCEPHALITOGENIC PROTEIN OF HUMAN ORIGIN: SOME CHEMICAL AND BIOLOGICAL PROPERTIES.一种人类源致脑炎蛋白：一些化学和生物学特性
Ann N Y Acad Sci. 1965 Mar 31;122:182-98. doi: 10.1111/j.1749-6632.1965.tb20202.x.
2
Response of human blood lymphocytes to tuberculin PPD in tissue culture.人血淋巴细胞在组织培养中对结核菌素纯蛋白衍生物的反应。
Immunology. 1967 Apr;12(4):417-29.
3
Demonstration of sensitized lymphocytes in blood.血液中致敏淋巴细胞的检测
J Clin Pathol. 1971 Mar;24(2):179-81. doi: 10.1136/jcp.24.2.179.
4
Sensitization of blood lymphocytes to possible antigens in neurological disease.血液淋巴细胞对神经疾病中可能的抗原的致敏作用。
Eur Neurol. 1970;4(5):257-66. doi: 10.1159/000114027.
5
Lymphocyte transformation in vitro measured by tritiated thymidine uptake. I. Lymphocyte culture techniques.通过氚标记胸腺嘧啶核苷摄取法体外测定淋巴细胞转化。I. 淋巴细胞培养技术。
Int Arch Allergy Appl Immunol. 1970;37(5):506-31. doi: 10.1159/000230240.
6
The macrophage electrophoretic migration (MEM) test for lymphocyte sensitization. A study of the kinetics.用于淋巴细胞致敏的巨噬细胞电泳迁移（MEM）试验。动力学研究。
Clin Exp Immunol. 1973 May;14(1):37-45.
7
Specific lymphocyte sensitization in cancer: is there a common antigen in human malignant neoplasia?癌症中的特异性淋巴细胞致敏：人类恶性肿瘤中是否存在共同抗原？
Br Med J. 1971 Jun 12;2(5762):613-7. doi: 10.1136/bmj.2.5762.613.
8
Lymphocyte sensitisation: an in-vitro test for cancer?淋巴细胞致敏：一种癌症的体外检测方法？
Lancet. 1970 Dec 26;2(7687):1337-41. doi: 10.1016/s0140-6736(70)92361-5.