Field E J, Caspary E A
Br Med J. 1972 Nov 4;4(5835):261-3. doi: 10.1136/bmj.4.5835.261.
Lymphocytes from patients with multiple sclerosis are sensitized to carcinoembryonic antigen (C.E.A.) in almost the same degree as are those from subjects with cancer. During pregnancy and the early puerperium there is an even higher degree of cellular sensitization to C.E.A. Patients with neurological diseases other than multiple sclerosis also show significant sensitization to C.E.A. though of less degree than do those with multiple sclerosis. Sensitization to C.E.A. is thus not specifically characteristic of cancer. The unexpected sensitization in multiple sclerosis may be associated with the pronounced degree of gliosis found in that condition.
多发性硬化症患者的淋巴细胞对癌胚抗原（C.E.A.）的致敏程度几乎与癌症患者的淋巴细胞相同。在怀孕期间和产后早期，对C.E.A.的细胞致敏程度更高。除多发性硬化症外的其他神经疾病患者也表现出对C.E.A.的显著致敏，尽管程度低于多发性硬化症患者。因此，对C.E.A.的致敏并非癌症所特有的特征。多发性硬化症中这种意外的致敏可能与该疾病中发现的明显胶质增生程度有关。
