Frost P
Immunology. 1974 Oct;27(4):609-16.
Evidence is presented to substantiate an earlier report that macrophages are the operative cells in the initiation of lymphocyte trapping. Several procedures which increase phagocytosis in mice of a soluble antigen (BGG), including transfer of specific serum or of adherent and non-adherent immune cells, or the transfer of sensitized macrophages, enhance the trapping potential of BGG. Animals tolerant to BGG trapped effectively when challenged with aggregated BGG, or when passively immunized and challenged with soluble BGG. The trapping defect in tolerant animals is thus due to a specific defect in immune responsiveness rather than an inherent failure of the trap mechanism. The dissociation between trapping and immune responsiveness is discussed.
有证据证实了先前的一份报告，即巨噬细胞是淋巴细胞滞留起始过程中的起作用细胞。几种可增加小鼠对可溶性抗原（BGG）吞噬作用的程序，包括转移特异性血清、黏附性和非黏附性免疫细胞，或转移致敏巨噬细胞，均可增强BGG的滞留潜力。对BGG耐受的动物在用聚集的BGG攻击时，或被动免疫并用可溶性BGG攻击时，能有效地滞留。因此，耐受动物的滞留缺陷是由于免疫反应性的特异性缺陷，而非滞留机制本身的失败。本文讨论了滞留与免疫反应性之间的分离。
