维生素A缺乏对大鼠局部淋巴结中抗原刺激的外周淋巴细胞捕获的影响。
The effect of vitamin A depletion on antigen-stimulated trapping of peripheral lymphocytes in local lymph nodes of rats.
作者信息
Takagi H, Nakano K
出版信息
Immunology. 1983 Jan;48(1):123-8.
The effect of vitamin A depletion on antigen-stimulated trapping of peripheral lymphocytes in lymphatic organs was studied in rats. Distribution of [3H]-uridine-labelled syngenic peripheral lymphocytes was quantified by assaying radioactive content of brachial and axillary lymph nodes, spleen and liver of normal and vitamin A-depleted F344/Ducrj rats immunized with sheep red blood cells. Localization of labelled cells in the ipsilateral brachial lymph nodes of the normal rats was stimulated by three times upon immunization with sheep erythrocytes as compared with the contralateral nodes. Recruitment of cells in axillary lymph nodes, spleen and liver was not significantly different from non-immunized values. The vitamin A-depleted rats exhibited marked deterioration in antigen-stimulated trapping of labelled cells in the draining brachial lymph nodes. These results suggest that this effect of vitamin A depletion is due to derangement of integrity of lymphocyte-trapping mechanism in the draining lymph nodes and not to any change in nature of lymphocytes per se.
在大鼠中研究了维生素A缺乏对抗原刺激的外周淋巴细胞在淋巴器官中捕获的影响。通过测定用绵羊红细胞免疫的正常和维生素A缺乏的F344/Ducrj大鼠的肱和腋窝淋巴结、脾脏和肝脏的放射性含量，对[3H]-尿苷标记的同基因外周淋巴细胞的分布进行了定量。与对侧淋巴结相比，正常大鼠在用绵羊红细胞免疫时，同侧肱淋巴结中标记细胞的定位受到三次刺激。腋窝淋巴结、脾脏和肝脏中细胞的募集与未免疫的值没有显著差异。维生素A缺乏的大鼠在引流肱淋巴结中抗原刺激的标记细胞捕获方面表现出明显恶化。这些结果表明，维生素A缺乏的这种影响是由于引流淋巴结中淋巴细胞捕获机制完整性的紊乱，而不是淋巴细胞本身性质的任何变化。
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