人IgD的结构与生物学功能。十二。慢性淋巴细胞白血病患者中抗IgD对PHA反应性的增强作用。

Structure and biological functions of human IgD. XII. Anti-IgD enhancement of PHA responsiveness in patients with chronic lymphocytic leukaemia.

作者信息

Kermani-Arab V, Leslie G A, Burger D R

出版信息

Clin Exp Immunol. 1977 Dec;30(3):450-6.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1541138/

Abstract

Specifically purifed anti-human delta stimulated the in vitro incorporation of [3H]thymidine by human peripheral lymphocytes from patients with chronic lymphocytic leukaemia (CLL). The peak response varied between individuals; those with 5--52% IgD-bearing lymphocytes exhibited maximum stimulation at 3 days, whereas a patient with only 1% IgD-bearing cells showed optimal activation at 6 days. In agreement with others, our data indicated that, in most instances, lymphocytes from patients with CLL respond poorly to PHA. One of the most important findings in this study is the enhancement of PHA responsiveness by anti-delta. Lymphocytes that exhibited reduced responsiveness to PHA alone, when pre-treated with anti-delta, showed transformation greater than the sum of the anti-delta plus PHA responses.

摘要

特异性纯化的抗人δ抗体刺激了慢性淋巴细胞白血病（CLL）患者外周血淋巴细胞在体外对[3H]胸腺嘧啶核苷的掺入。峰值反应在个体间有所不同；携带IgD淋巴细胞占5% - 52%的患者在3天时表现出最大刺激，而携带IgD细胞仅占1%的一名患者在6天时显示出最佳激活。与其他人的研究结果一致，我们的数据表明，在大多数情况下，CLL患者的淋巴细胞对PHA反应较差。本研究中最重要的发现之一是抗δ抗体增强了PHA反应性。单独对PHA反应性降低的淋巴细胞，在用抗δ抗体预处理后，其转化程度大于抗δ抗体加PHA反应的总和。

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本文引用的文献

1

Impaired phytohaemagglutinin-induced cytotoxicity in vitro of lymphocytes from patients with Hodgkin's disease or chronic lymphatic leukaemia.霍奇金病或慢性淋巴细胞白血病患者淋巴细胞在体外对植物血凝素诱导的细胞毒性受损。

Clin Exp Immunol. 1967 May;2(3):351-60.

2

Studies on the secretory immunologic system of fowl. 3. Serum and secretory IgA of the chicken.家禽分泌免疫系统的研究。3. 鸡的血清和分泌型IgA

J Immunol. 1973 Jan;110(1):1-9.

3

Idiotypic specificity of surface immunoglobulin and the maturation of leukemic bone-marrow-derived lymphocytes.表面免疫球蛋白的独特型特异性与白血病骨髓来源淋巴细胞的成熟

Proc Natl Acad Sci U S A. 1974 Nov;71(11):4487-90. doi: 10.1073/pnas.71.11.4487.

4

IgD: a major immunoglobulin on the surface of lymphocytes from patients with chronic lymphatic leukemia.免疫球蛋白D：慢性淋巴细胞白血病患者淋巴细胞表面的一种主要免疫球蛋白。

J Immunol. 1974 May;112(5):1952-4.

5

Immunoglobulins on the surface of neoplastic lymphocytes.肿瘤淋巴细胞表面的免疫球蛋白。

N Engl J Med. 1972 Aug 10;287(6):272-6. doi: 10.1056/NEJM197208102870603.

6

Lymphocyte subpopulations in chronic lymphocytic leukemia. Characterization by cell surface markers, cytotoxic activity, and mitogenic stimulation.

Scand J Immunol. 1974;3(3):303-10. doi: 10.1111/j.1365-3083.1974.tb01261.x.

7

Immunoglobulin D as a lymphocyte receptor.作为淋巴细胞受体的免疫球蛋白D

J Exp Med. 1973 Oct 1;138(4):965-72. doi: 10.1084/jem.138.4.965.

8

The effect of antilymphocyte antibody on lymphocyte transformation. Selective suppression of mitogen, mixed lymphocyte culture, and antigen stimulation of human lymphocytes.抗淋巴细胞抗体对淋巴细胞转化的作用。对人淋巴细胞有丝分裂原、混合淋巴细胞培养及抗原刺激的选择性抑制。

Transplantation. 1974 Jun;17(6):541-50. doi: 10.1097/00007890-197406000-00001.

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Eur J Immunol. 1974 Nov;4(11):776-8. doi: 10.1002/eji.1830041114.

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