网状内皮系统的活性与抗体反应。III. III型肺炎球菌多糖的命运与抗体反应。
Activity of the reticuloendothelial system and the antibody response. III. The fate of type III pneumococcal polysaccharide and the antibody response.
作者信息
Sljivić V S, Warr G W
出版信息
Immunology. 1974 Dec;27(6):1009-22.
Pretreatment of mice with stilboestrol was shown to reduce the splenic direct PFC response to low, but not to high, immunizing doses of SIII. The fate of I-labelled SIII in control and stilboestrol-treated mice over a period of 3 weeks was observed. Stilboestrol-treated mice showed enhanced rate of clearance from the blood and hepatic uptake of I-labelled SIII, and a consistently depressed level of circulating I-labelled SIII. No consistent differences in splenic uptake of SIII between control and stilboestrol-treated mice were observed, but the excretion of radioactivity appeared to be slower in the latter group. The altered pattern of blood clearance and liver uptake of SIII in stilboestrol-treated mice is consistent with the potent stimulation of RES phagocytic activity induced by this agent, and it is suggested that the increased sequestration of SIII in stilboestrol-treated mice may be related to the observed effects of stilboestrol on the antibody response to this antigen.
已表明，用己烯雌酚对小鼠进行预处理可降低脾脏对低剂量而非高剂量免疫原性 SIII 的直接 PFC 反应。观察了在 3 周时间内对照小鼠和己烯雌酚处理小鼠体内 I 标记 SIII 的命运。己烯雌酚处理的小鼠显示出血液清除率增强以及肝脏对 I 标记 SIII 的摄取增加，并且循环中的 I 标记 SIII 水平持续降低。未观察到对照小鼠和己烯雌酚处理小鼠在脾脏对 SIII 的摄取上存在一致差异，但后一组的放射性排泄似乎较慢。己烯雌酚处理小鼠中 SIII 的血液清除和肝脏摄取模式改变与该药物诱导的 RES 吞噬活性的强烈刺激一致，并且有人提出，己烯雌酚处理小鼠中 SIII 隔离增加可能与观察到的己烯雌酚对该抗原抗体反应的影响有关。
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