用小鼠抗血清致敏后大鼠的腹膜过敏反应。
Peritoneal anaphylaxis in the rat after sensitization with mouse antiserum.
作者信息
Spicer B A, Ross J W, Sharpe T J, Smith H
出版信息
Int Arch Allergy Appl Immunol. 1978;56(6):493-9. doi: 10.1159/000232064.
Passive peritoneal anaphylaxis in rats, sensitized with mouse antiserum, had characteristics of an IgE-mediated reaction, in that the serum was heat-labile and pretreatment of the rats with disodium cromoglycate (DSCG), or sodium nivimedone, inhibited the release of both histamine and slow-reacting substance of anaphylaxis (SRS-A). Sodium nivimedone was more potent than DSCG as an inhibitor of histamine release. Peak concentrations of histamine and SRS-A in the peritoneal fluids of the rats, were reached within 2 min of antigen challenge and fell to control levels after 20-30 min.
用小鼠抗血清致敏的大鼠被动性腹膜过敏反应具有IgE介导反应的特征，即血清对热不稳定，用色甘酸二钠（DSCG）或尼维美酮钠预处理大鼠可抑制组胺和过敏反应慢反应物质（SRS-A）的释放。尼维美酮钠作为组胺释放抑制剂比DSCG更有效。大鼠腹膜液中组胺和SRS-A的峰值浓度在抗原攻击后2分钟内达到，并在20-30分钟后降至对照水平。
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