Oberman H A, Barnes B A, Friedman B A
Transfusion. 1978 Mar-Apr;18(2):137-41. doi: 10.1046/j.1537-2995.1978.18278160574.x.
The risk of abbreviating the major crossmatch in urgent situations by issuing blood after an "immediate spin" phase was evaluated by a retrospective study of 82,647 crossmatches performed on serum from approximately 13,950 patients. Although the initial screening test for unexpected antibodies for all patients failed to show agglutination or hemolysis of the reagent red blood cells, agglutination was subsequently noted during at least one crossmatch performed for 148 of them. Further evaluation of these patients' serums indicated that most positive reactions were due to weakly reactive low thermal amplitude antibodies. Eight of the incompatible crossmatches were related to antibodies in the Kell, Kidd or Rh systems, and a ninth antibody, anti-E, was identified through subsequent evaluation of a cold antibody-induced crossmatch incompatibility. Issuance of blood in urgent situations after an "immediate spin" phase of the crossmatch, for patients whose red blood cells have been typed, and whose serums have been screened for unexpected antibodies, has a low level of risk.
通过对约13950名患者血清进行的82647次交叉配血试验进行回顾性研究，评估了在“即刻离心”阶段后紧急情况下省略主侧交叉配血的风险。尽管对所有患者进行的意外抗体初始筛查试验未显示试剂红细胞发生凝集或溶血，但随后在其中148名患者至少一次交叉配血试验中发现了凝集现象。对这些患者血清的进一步评估表明，大多数阳性反应是由于反应较弱的低热幅度抗体所致。8次不相容交叉配血与凯尔、基德或Rh系统中的抗体有关，通过对冷抗体诱导的交叉配血不相容性进行后续评估，鉴定出第九种抗体抗-E。对于红细胞已分型且血清已筛查意外抗体的患者，在交叉配血的“即刻离心”阶段后紧急情况下输血，风险较低。
