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新西兰黑鼠的遗传学研究。I. 自发自身抗体产生

Genetic studies in NZB mice. I. Spontaneous autoantibody production.

作者信息

Raveché E S, Steinberg A D, Klassen L W, Tjio J H

出版信息

J Exp Med. 1978 May 1;147(5):1487-1502. doi: 10.1084/jem.147.5.1487.

DOI:10.1084/jem.147.5.1487
PMID:418139
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2184274/
Abstract

The appearance of naturally occurring thymocytotoxic autoantibodies (NTA) and spontaneously produced antibodies to single-stranded DNA (ssDNA) was studied in NZB, and DBA/2 mice and their F1 and backcross progeny. NTA production was markedly decreased in males; however, castrated males produced quantities of NTA similar to those of females. Because the amount of NTA was influenced by sex hormones, it was necessary to gonadectomize all progeny to determine the mode of inheritance. Such studies suggested that NTA production was determined by a single locus with a gene dosage (codominant) mode of expression. The spontaneous production of antibodies to ssDNA appeared to be inherited as a single dominant genetic trait. The quantity of anti-ssDNA was also found to be under additional regulation; either a gene dosage effect or more likely a regulatory gene. The genes controlling the presence and quantity of ssDNA antibodies were not linked to the gene controlling the appearance of NTA.

摘要

对新西兰黑鼠、DBA/2小鼠及其F1代和回交后代中自然产生的胸腺细胞毒性自身抗体（NTA）以及自发产生的单链DNA（ssDNA）抗体的出现情况进行了研究。雄性小鼠的NTA产生明显减少；然而，去势雄性小鼠产生的NTA量与雌性小鼠相似。由于NTA的量受性激素影响，因此有必要对所有后代进行性腺切除以确定遗传模式。此类研究表明，NTA的产生由一个具有基因剂量（共显性）表达模式的单一位点决定。对ssDNA抗体的自发产生似乎作为单一显性遗传性状遗传。还发现抗ssDNA的量受到额外调控；要么是基因剂量效应，要么更可能是一个调控基因。控制ssDNA抗体存在和量的基因与控制NTA出现的基因不连锁。

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本文引用的文献

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OBSERVATIONS ON NZB/B1 MICE; DIFFERENTIAL FERTILITY IN RECIPROCAL CROSSES AND THE TRANSMISSION OF THE AUTO-IMMUNE HAEMOLYTIC ANAEMIA TO NZB/B1 X NZC/B1 HYBRIDS.对NZB/B1小鼠的观察；正反交中的差异生育力以及自身免疫性溶血性贫血向NZB/B1×NZC/B1杂交种的传递。
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The characteristics of F1 and backcross hybrids between "high leukaemia" (AKR) and "autoimmune" (NZB) mouse strains.“高白血病”（AKR）和“自身免疫”（NZB）小鼠品系之间的F1代及回交杂种的特征
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Genetic investigations of autoimmune disease in mice.小鼠自身免疫性疾病的遗传学研究。
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The nature of the antigenic determinant in a genetic control of the antibody response.抗体应答遗传控制中抗原决定簇的性质。
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