Chiller J M, Habicht G S, Weigle W O
Proc Natl Acad Sci U S A. 1970 Mar;65(3):551-6. doi: 10.1073/pnas.65.3.551.
The reconstitution of the immune response of lethally irradiated mice to human gamma-globulin is dependent on the synergistic action of bone marrow with thymus cells. Immunologic unresponsiveness appears to involve a functional defect at each of these cellular levels, inasmuch as neither bone marrow nor thymus cells from unresponsive donors are capable of demonstrating synergism in combination with their normal counterpart.
受致死剂量照射的小鼠对人γ球蛋白免疫反应的重建取决于骨髓与胸腺细胞的协同作用。免疫无反应性似乎涉及这些细胞水平中每一个的功能缺陷,因为来自无反应供体的骨髓细胞和胸腺细胞与它们的正常对应物组合时均无法表现出协同作用。