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1
Cellular sites of immunologic unresponsiveness.免疫无反应性的细胞位点。
Proc Natl Acad Sci U S A. 1970 Mar;65(3):551-6. doi: 10.1073/pnas.65.3.551.
2
Antibody formation by bone marrow cells in irradiated mice. I. Thymus-dependent and thymus-independent responses to sheep erythrocytes.受照射小鼠骨髓细胞的抗体形成。I. 对绵羊红细胞的胸腺依赖性和非胸腺依赖性反应。
Immunology. 1971 Jul;21(1):113-21.
3
Fate of different cell populations during induction of immunological unresponsiveness.免疫无反应性诱导过程中不同细胞群体的命运
Transplant Proc. 1972 Sep;4(3):373-6.
4
Cells involved in the immune response. XV. The organ source of the antigen reactive cells in the normal rabbit.参与免疫反应的细胞。十五、正常兔体内抗原反应性细胞的器官来源。
Int Arch Allergy Appl Immunol. 1970;38(3):269-81. doi: 10.1159/000230280.
5
Immunological memory in mice. II. Cell interactions in the secondary immune response studies by means of immunoglobulin allotype markers.小鼠的免疫记忆。II. 通过免疫球蛋白同种异型标记研究二次免疫应答中的细胞相互作用。
J Exp Med. 1970 Jun 1;131(6):1109-20. doi: 10.1084/jem.131.6.1109.
6
The asynchronous development of immunological memory in helper (T) and precursor (B) cell lines.辅助性（T）细胞系和前体（B）细胞系中免疫记忆的异步发育。
Eur J Immunol. 1971 Dec;1(6):413-21. doi: 10.1002/eji.1830010602.
7
Stimulation of humoral antibody formation by polyanions. 3. Restoration of the immune response to sheep red blood cells by polyanions in thymectomized and lethally irradiated mice protected with bone marrow cells.多聚阴离子对体液抗体形成的刺激作用。3. 多聚阴离子对经胸腺切除和致死性照射并用骨髓细胞保护的小鼠体内针对绵羊红细胞免疫反应的恢复作用。
Eur J Immunol. 1971 Aug;1(4):302-4. doi: 10.1002/eji.1830010418.
8
Role of T lymphocytes in the humoral immune response. I. Proliferation of B lymphocytes in thymus-deprived mice.T淋巴细胞在体液免疫反应中的作用。I. 无胸腺小鼠中B淋巴细胞的增殖。
J Immunol. 1974 Nov;113(5):1438-45.
9
[Recovery of immunological functions in lethally irradiated mice grafted with preirradiated hematopoietic bone marrow].[接受经预照射的造血骨髓移植的致死性照射小鼠免疫功能的恢复]
C R Seances Soc Biol Fil. 1972;166(6):965-8.
10
Organ distribution of immunocompetent cells in guinea pigs. II. Spleen, lymph node, bone marrow, or thymus cells in the restoration of the splenic plaque-forming cell response to sheep erythrocytes after irradiation.豚鼠免疫活性细胞的器官分布。II. 照射后脾、淋巴结、骨髓或胸腺细胞对绵羊红细胞脾空斑形成细胞反应的恢复作用
Int Arch Allergy Appl Immunol. 1976;52(1-4):325-30.

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Immunogenicity of Isogenic IgG in Aggregates and Immune Complexes.同基因IgG在聚集体和免疫复合物中的免疫原性。
PLoS One. 2017 Jan 23;12(1):e0170556. doi: 10.1371/journal.pone.0170556. eCollection 2017.
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Validation of the interleukin-10 knockout mouse model of colitis: antitumour necrosis factor-antibodies suppress the progression of colitis.结肠炎白细胞介素-10基因敲除小鼠模型的验证：抗肿瘤坏死因子抗体可抑制结肠炎进展。
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Retroviral gene therapy with an immunoglobulin-antigen fusion construct protects from experimental autoimmune uveitis.用免疫球蛋白 - 抗原融合构建体进行逆转录病毒基因治疗可预防实验性自身免疫性葡萄膜炎。
J Clin Invest. 2000 Jul;106(2):245-52. doi: 10.1172/JCI9168.
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Biological insights from clinical trials with anti-TNF therapy.抗TNF治疗临床试验的生物学见解。
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7
Genetically transferred central and peripheral immune tolerance via retroviral-mediated expression of immunogenic epitopes in hematopoietic progenitors or peripheral B lymphocytes.通过逆转录病毒介导在造血祖细胞或外周B淋巴细胞中表达免疫原性表位实现基因转移的中枢和外周免疫耐受。
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8
Epitope-specific tolerance induction with an engineered immunoglobulin.利用工程化免疫球蛋白诱导表位特异性耐受。
Proc Natl Acad Sci U S A. 1996 May 14;93(10):5019-24. doi: 10.1073/pnas.93.10.5019.
9
Mice transgenic for a soluble form of murine CTLA-4 show enhanced expansion of antigen-specific CD4+ T cells and defective antibody production in vivo.转染了可溶性鼠CTLA-4的小鼠在体内表现出抗原特异性CD4+ T细胞的扩增增强以及抗体产生缺陷。
J Exp Med. 1994 Mar 1;179(3):809-17. doi: 10.1084/jem.179.3.809.
10
Control of autoantibody affinity by selection against amino acid replacements in the complementarity-determining regions.通过针对互补决定区中的氨基酸替换进行选择来控制自身抗体亲和力。
Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12917-21. doi: 10.1073/pnas.91.26.12917.

本文引用的文献

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Antibody formation in vitro.体外抗体形成。
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2
The thymus and the precursors of antigen reactive cells.胸腺与抗原反应性细胞的前体。
Nature. 1967 Nov 18;216(5116):659-63. doi: 10.1038/216659a0.
3
A requirement for two cell types for antibody formation in vitro.体外抗体形成需要两种细胞类型。
Science. 1967 Dec 22;158(3808):1573-5. doi: 10.1126/science.158.3808.1573.
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Thymus-marrow cell combinations. Synergism in antibody production.胸腺-骨髓细胞组合。抗体产生中的协同作用。
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Specific tolerance to sheep erythrocytes in mouse bone marrow cells.小鼠骨髓细胞对绵羊红细胞的特异性耐受性
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6
Antibody-producing cells in rabbits injected with soluble BSA. I. Hemolytic plaque assay.注射可溶性牛血清白蛋白的兔体内产生抗体的细胞。I. 溶血空斑试验。
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7
Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes.免疫反应中的细胞间相互作用。II. 给受照射小鼠输注骨髓、胸腺或胸导管淋巴细胞后溶血素形成细胞的来源。
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8
Persistence of immunogenicity of antigen after uptake by macrophages.巨噬细胞摄取抗原后抗原免疫原性的持续性。
J Exp Med. 1968 May 1;127(5):915-26. doi: 10.1084/jem.127.5.915.
9
Application of a sensitive radial immunodiffusion method for the detection of thyroglobulin autoprecipitins.一种用于检测甲状腺球蛋白自身沉淀素的灵敏放射免疫扩散法的应用。
Int Arch Allergy Appl Immunol. 1969;35(4):335-44. doi: 10.1159/000230186.
10
Immune paralysis of thymus cells by bovine serum albumin.牛血清白蛋白导致胸腺细胞免疫麻痹。
Nature. 1968 Nov 9;220(5167):611. doi: 10.1038/220611a0.

免疫无反应性的细胞位点。

Cellular sites of immunologic unresponsiveness.

作者信息

Chiller J M, Habicht G S, Weigle W O

出版信息

Proc Natl Acad Sci U S A. 1970 Mar;65(3):551-6. doi: 10.1073/pnas.65.3.551.

DOI:10.1073/pnas.65.3.551
PMID:4192271
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC282942/
Abstract

The reconstitution of the immune response of lethally irradiated mice to human gamma-globulin is dependent on the synergistic action of bone marrow with thymus cells. Immunologic unresponsiveness appears to involve a functional defect at each of these cellular levels, inasmuch as neither bone marrow nor thymus cells from unresponsive donors are capable of demonstrating synergism in combination with their normal counterpart.

摘要

受致死剂量照射的小鼠对人γ球蛋白免疫反应的重建取决于骨髓与胸腺细胞的协同作用。免疫无反应性似乎涉及这些细胞水平中每一个的功能缺陷，因为来自无反应供体的骨髓细胞和胸腺细胞与它们的正常对应物组合时均无法表现出协同作用。