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用甲型和乙型流感病毒对动物进行实验性感染。

Experimental infection of animals with influenzavirus types A and B.

作者信息

Paniker C K, Nair C M

出版信息

Bull World Health Organ. 1972;47(4):461-3.

PMID:4196340
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2480865/
Abstract

The knowledge that domestic cats were susceptible to infection with freshly isolated A/Hong Kong/68 influenzavirus led to studies on the susceptibility of some other animal species to this virus, as well as to studies on the ability of egg-passaged Hong Kong virus and an Asian virus to infect cats. The ability of a recent isolate of influenzavirus B to infect these animals was also studied. Macaca radiata monkeys could be infected with fresh isolates of A/Hong Kong virus by intranasal instillation or by contact with infected animals. They could also be infected with influenzavirus B by intranasal challenge, but contact transmission was not demonstrated. Mongrel dogs were found to be susceptible to A/Hong Kong/68 virus by intranasal instillation, but not to type B virus. Domestic cats could be infected with A/Hong Kong/68 virus passaged 6 times in eggs. They were also susceptible to infection with an established laboratory strain of Asian virus. Cats could be infected with influenzavirus B either by intranasal challenge or by contact with infected animals. In no case was clinical illness found following infection, but the infected animals shed virus from the throat and developed haemagglutination inhibiting antibodies.

摘要

家猫易感染新分离出的A/香港/68流感病毒这一发现,引发了对其他一些动物物种对该病毒易感性的研究,以及对经鸡胚传代的香港病毒和一种亚洲病毒感染猫的能力的研究。还研究了一种近期分离出的B型流感病毒感染这些动物的能力。放射猴可通过滴鼻或与感染动物接触感染A/香港病毒的新鲜分离株。它们也可通过滴鼻感染B型流感病毒,但未证实有接触传播。发现杂种狗通过滴鼻易感染A/香港/68病毒,但不易感染B型病毒。家猫可感染经鸡胚传代6次的A/香港/68病毒。它们也易感染一种已建立的亚洲病毒实验室毒株。猫可通过滴鼻或与感染动物接触感染B型流感病毒。感染后均未发现临床疾病,但感染动物的咽喉部排出病毒并产生血凝抑制抗体。

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