Stark R D, Finnegan P, Bishop J M
Br Med J. 1973 Sep 1;3(5878):467-70. doi: 10.1136/bmj.3.5878.467.
Five patients with chronic bronchitis and pulmonary hypertension were treated with oxygen in their homes for periods of between 6 and 24 months. Oxygen was supplied for 15 hours daily from cylinders or from an oxygen concentrator and few practical difficulties arose. After 23 to 59 weeks of treatment there were significant decreases in pulmonary arterial pressure and vascular resistance, and four of the five patients no longer had pulmonary hypertension at rest. Two of these patients had shown little response after three weeks of treatment. There was a reduction in the number of episodes of congestive cardiac failure compared with the corresponding period before treatment. Two of the patients improved enough to return to work. These results are encouraging enough to justify a controlled trial of the treatment in a large number of patients.
五名患有慢性支气管炎和肺动脉高压的患者在家中接受了为期6至24个月的吸氧治疗。氧气通过氧气瓶或制氧机每天供应15小时，几乎没有出现实际困难。经过23至59周的治疗，肺动脉压和血管阻力显著降低，五名患者中有四名在静息时不再患有肺动脉高压。其中两名患者在治疗三周后几乎没有反应。与治疗前的相应时期相比，充血性心力衰竭发作次数有所减少。两名患者病情改善到足以重返工作岗位。这些结果令人鼓舞，足以证明对大量患者进行该治疗的对照试验是合理的。
