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食管和贲门恶性肿瘤的外科治疗:对1961年至1975年15年间292例患者治疗结果的回顾。

The surgical management of malignant tumours of the oesophagus and cardia: a review of the results in 292 patients treated over a 15-year period (1961--75).

作者信息

Jackson J W, Cooper D K, Guvendik L, Reece-Smith H

出版信息

Br J Surg. 1979 Feb;66(2):98-104. doi: 10.1002/bjs.1800660207.

Abstract

Of 292 patients, excision of the tumour with replacement by stomach or jejunum was carried out in 216 in whom the lesion was considered operable on both technical and general grounds, intubation was performed in 45 and the remaining 31 were managed without operation. Of the 216 in whom resection was performed, only 20 per cent were free from local spread, lymph node involvement or secondary deposits at the time of operation. Hospital mortality was 18 per cent and did not significantly differ between one 5-year period and another. Survival at 1 year was 54 per cent, at 2 years 25 per cent and at 5 years 14 per cent. The average length of survival following intubation was 2.6 months and following non-operative management 2.8 months. The poor average survival of between 3.5 and 5 months obtained in those patients with secondary deposits at the time of resection suggests that resection is of questionable value in this group. There was a marked difference in survival following Roux loop procedures compared with upper partial gastrectomy for tumours of the lower third and cardia in patients without lymph node involvement or secondary deposits, strongly suggesting that upper partial gastrectomy, although a rather simpler and quicker operation, is not the operation of choice in these patients. On 31 December 1976, after a minimum follow-up of 1 year, there were only 22 patients still alive of the original 292 (7.5 per cent).

摘要

292例患者中,216例因技术和全身状况考虑病变可切除,行肿瘤切除并以胃或空肠替代;45例行插管治疗;其余31例未行手术。在接受切除手术的216例患者中,仅20%在手术时无局部扩散、淋巴结受累或远处转移。医院死亡率为18%,在不同的5年期间无显著差异。1年生存率为54%,2年生存率为25%,5年生存率为14%。插管后的平均生存时间为2.6个月,非手术治疗后的平均生存时间为2.8个月。切除时已有远处转移的患者平均生存时间较差,在3.5至5个月之间,这表明该组患者行切除手术的价值值得怀疑。对于无淋巴结受累或远处转移的胃下1/3和贲门部肿瘤患者,Roux袢手术与上半胃切除术相比,生存情况有显著差异,强烈提示上半胃切除术虽然是一种相对简单快捷的手术,但并非这些患者的首选手术。截至1976年12月31日,在至少随访1年后,最初的292例患者中仅22例仍存活(7.5%)。

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