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1
Isolation and identification by sequence analysis of experimentally induced guinea pig amyloid fibrils.通过序列分析对实验诱导的豚鼠淀粉样纤维进行分离和鉴定。
J Exp Med. 1974 Sep 1;140(3):871-6. doi: 10.1084/jem.140.3.871.
2
Murine amyloid protein AA in casein-induced experimental amyloidosis.酪蛋白诱导的实验性淀粉样变性中的小鼠淀粉样蛋白AA
Lab Invest. 1977 Apr;36(4):420-7.
3
A 25,000 molecular weight protein constituent of human amyloid fibrils related to amyloid protein AA.
Arch Biochem Biophys. 1975 Nov;171(1):197-205. doi: 10.1016/0003-9861(75)90024-7.
4
Mouse amyloid protein AA: Homology with nonimmunoglobulin protein of human and monkey amyloid substance.小鼠淀粉样蛋白AA：与人及猴淀粉样物质的非免疫球蛋白蛋白的同源性。
Proc Natl Acad Sci U S A. 1976 Mar;73(3):964-7. doi: 10.1073/pnas.73.3.964.
5
Amyloid fibril protein AA in Papua New Guinean amyloidosis.巴布亚新几内亚淀粉样变性中的淀粉样原纤维蛋白AA
Clin Exp Immunol. 1976 Apr;24(1):49-53.
6
An experimental model in mink for studying the relation between amyloid fibril protein AA and the related serum protein SAA.一种用于研究淀粉样原纤维蛋白AA与相关血清蛋白SAA之间关系的水貂实验模型。
Scand J Immunol. 1975;4(8):811-6. doi: 10.1111/j.1365-3083.1975.tb03721.x.
7
Isolation and characterization of a kappa amyloid fibril protein.
Scand J Immunol. 1985 Sep;22(3):245-50. doi: 10.1111/j.1365-3083.1985.tb01877.x.
8
A serum AA-like protein as a common constituent of secondary amyloid fibrils.一种血清中类似AA的蛋白质作为继发性淀粉样原纤维的常见成分。
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Ultrastructural studies on renal peritubular amyloid experimentally induced in guinea pigs. I. General aspects.豚鼠实验性诱导肾周肾小管淀粉样变的超微结构研究。I. 一般情况。
Lab Invest. 1968 Jul;19(1):122-31.
10
Variant apolipoprotein AI as a major constituent of a human hereditary amyloid.变异载脂蛋白AI作为人类遗传性淀粉样蛋白的主要成分。
Biochem Biophys Res Commun. 1988 Oct 31;156(2):762-8. doi: 10.1016/s0006-291x(88)80909-4.

引用本文的文献

1
Amyloid deposition in the digestive tract in casein-induced experimental amyloidosis in mice.酪蛋白诱导的小鼠实验性淀粉样变性中消化道的淀粉样蛋白沉积。
J Gastroenterol. 1994 Feb;29(1):6-14. doi: 10.1007/BF01229066.
2
Redistribution of amyloid deposits.淀粉样沉积物的重新分布。
Am J Pathol. 1980 Jun;99(3):539-50.
3
Immunocytochemical identification of amyloid in formalin-fixed paraffin sections.福尔马林固定石蜡切片中淀粉样蛋白的免疫细胞化学鉴定
Histochemistry. 1981;72(2):161-71. doi: 10.1007/BF00517130.
4
Idiopathic amyloidosis in the stone marten (Martes foina): identification of amyloid fibril proteins in tissue sections using the immunoperoxidase technique.石貂（Martes foina）特发性淀粉样变性：利用免疫过氧化物酶技术鉴定组织切片中的淀粉样纤维蛋白。
Blut. 1980 Dec;41(6):465-8. doi: 10.1007/BF01007773.
5
Senile cerebral amyloid. Prealbumin as a common constituent in the neuritic plaque, in the neurofibrillary tangle, and in the microangiopathic lesion.老年脑淀粉样变。前白蛋白作为神经炎性斑块、神经原纤维缠结及微血管病变中的常见成分。
Am J Pathol. 1982 Apr;107(1):41-50.
6
Activities of lysosomal enzymes and levels of serum amyloid A (SAA) in blood plasma of hamsters during casein induction of AA-amyloidosis.在酪蛋白诱导的AA淀粉样变性过程中，仓鼠血浆中溶酶体酶的活性及血清淀粉样蛋白A（SAA）水平。
Br J Exp Pathol. 1985 Jun;66(3):279-92.
7
Systemic amyloidosis in transgenic mice carrying the human mutant transthyretin (Met30) gene. Pathologic similarity to human familial amyloidotic polyneuropathy, type I.携带人类突变甲状腺素运载蛋白（Met30）基因的转基因小鼠中的系统性淀粉样变性。与人类I型家族性淀粉样多神经病的病理相似性。
Am J Pathol. 1991 Feb;138(2):403-12.
8
Heterogeneity of human serum amyloid A protein. Five different variants from one individual demonstrated by cDNA sequence analysis.人血清淀粉样蛋白A的异质性。通过cDNA序列分析显示来自同一个体的五种不同变体。
Biochem J. 1990 May 15;268(1):187-93. doi: 10.1042/bj2680187.
9
Conformational flexibility of the serum amyloid precursor SAA.血清淀粉样前体蛋白SAA的构象灵活性
Br J Exp Pathol. 1976 Oct;57(5):582-92.
10
Kinetics of serum amyloid protein A in casein-induced murine amyloidosis.酪蛋白诱导的小鼠淀粉样变性中血清淀粉样蛋白A的动力学
J Clin Invest. 1977 Mar;59(3):412-7. doi: 10.1172/JCI108654.

本文引用的文献

1
The major proteins of human and monkey amyloid substance: Common properties including unusual N-terminal amino acid sequences.人类和猴子淀粉样物质的主要蛋白质：共同特性，包括不寻常的N端氨基酸序列。
FEBS Lett. 1971 Dec 1;19(2):169-173. doi: 10.1016/0014-5793(71)80506-9.
2
A protein sequenator.蛋白质测序仪。
Eur J Biochem. 1967 Mar;1(1):80-91. doi: 10.1007/978-3-662-25813-2_14.
3
The characterization of soluble amyloid prepared in water.在水中制备的可溶性淀粉样蛋白的特性
J Clin Invest. 1968 Apr;47(4):924-33. doi: 10.1172/JCI105784.
4
Analysis of amino acid phenylthiohydantoins by gas chromatography.气相色谱法分析氨基酸苯硫代乙内酰脲
J Biol Chem. 1969 Oct 25;244(20):5597-607.
5
Quantitative procedures for use with the Edman-Begg sequenator. Partial sequences of two unusual immunoglobulin light chains, Rzf and Sac.用于埃德曼-贝格蛋白质测序仪的定量方法。两种异常免疫球蛋白轻链Rzf和Sac的部分序列。
Biochemistry. 1971 Dec 21;10(26):4912-21. doi: 10.1021/bi00802a013.
6
The amino acid sequence of a major nonimmunoglobulin component of some amyloid fibrils.某些淀粉样纤维主要非免疫球蛋白成分的氨基酸序列。
J Clin Invest. 1972 Oct;51(10):2773-6. doi: 10.1172/JCI107098.
7
P-component of amyloid: amino-terminal sequence.
Biochem Biophys Res Commun. 1973 Sep 18;54(2):732-6. doi: 10.1016/0006-291x(73)91484-8.
8
Amino acid sequence of monkey amyloid protein A.猴淀粉样蛋白A的氨基酸序列。
Biochemistry. 1972 Aug 1;11(16):2934-8. doi: 10.1021/bi00766a002.
9
Amyloid fibril proteins: proof of homology with immunoglobulin light chains by sequence analyses.淀粉样纤维蛋白：通过序列分析证明与免疫球蛋白轻链的同源性。
Science. 1971 Jun 11;172(3988):1150-1. doi: 10.1126/science.172.3988.1150.

通过序列分析对实验诱导的豚鼠淀粉样纤维进行分离和鉴定。

Isolation and identification by sequence analysis of experimentally induced guinea pig amyloid fibrils.

作者信息

Skinner M, Cathcart E S, Cohen A S, Benson M D

出版信息

J Exp Med. 1974 Sep 1;140(3):871-6. doi: 10.1084/jem.140.3.871.

DOI:10.1084/jem.140.3.871
PMID:4213201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2139617/
Abstract

Amyloidosis was produced experimentally in guinea pigs by multiple casein injections. Amyloid fibrils were isolated and fractionated and a protein obtained that had an amino acid composition comparable with A protein, a unique nonimmunoglobulin constituent of secondary amyloid deposits. N-terminal sequence analysis demonstrated a sequence homologous with that of A proteins from human and monkey preparations but preceded by a 5-residue peptide which had an N-terminal histidine. A definite species specificity in A protein from human and guinea pig was identified on immunologic analysis.

摘要

通过多次注射酪蛋白在豚鼠中实验性地诱导出淀粉样变性。分离并分级淀粉样纤维，得到一种蛋白质，其氨基酸组成与A蛋白相当，A蛋白是继发性淀粉样沉积物中一种独特的非免疫球蛋白成分。N端序列分析表明，该序列与来自人和猴制剂的A蛋白序列同源，但前面有一个5个残基的肽段，其N端为组氨酸。免疫分析确定了人和豚鼠A蛋白之间存在明确的物种特异性。