过敏性和非过敏性养蜂人特应性背景的比较。

Comparison of the atopic background between allergic and non-allergic beekeepers.

作者信息

Miyachi S, Lessof M H, Kemeny D M, Green L A

出版信息

Int Arch Allergy Appl Immunol. 1979;58(2):160-6. doi: 10.1159/000232188.

Abstract

A study was carried out on beekeepers and their families. 34 subjects with a history of bee sting allergy and also a positive radioallergosorbent test (RAST) to honey bee venom were compared with 47 subjects with neither. 16 subjects in the bee allergy group (47%) had a history of atopic diseases as compared to 6 (13%) in the control group (p less than 0.01). 15 in the bee allergy group (44%) had at least one positive RAST to three common inhalant allergens as compared to 5 (11%) in the control group (p less than 0.01). These results suggest that, although bee sting allergy frequently affects non-atopic subjects, sensitization among beekeepers and their families occurs more readily in atopics. It is notable that a large proportion of patients injected with foreign proteins (the control group) either never develop venom-specific IgE antibodies or have suppressed their production.

摘要

对养蜂人及其家人进行了一项研究。将34名有蜂蜇过敏史且对蜜蜂毒液放射性变应原吸附试验（RAST）呈阳性的受试者与47名既无蜂蜇过敏史也无RAST阳性的受试者进行了比较。蜜蜂过敏组中有16名受试者（47%）有特应性疾病史，而对照组中有6名受试者（13%）有特应性疾病史（p<0.01）。蜜蜂过敏组中有15名受试者（44%）对三种常见吸入性变应原的RAST至少有一项呈阳性，而对照组中有5名受试者（11%）呈阳性（p<0.01）。这些结果表明，虽然蜂蜇过敏经常影响非特应性受试者，但养蜂人及其家人中的特应性个体更容易发生致敏。值得注意的是，很大一部分注射了外来蛋白质的患者（对照组）要么从未产生毒液特异性IgE抗体，要么抑制了其产生。