小鼠骨髓中前体细胞向胸腺来源细胞的分化。
Differentiation of thymus-derived cells from precursors in mouse bone marrow.
作者信息
el-Arini M O, Osoba D
出版信息
J Exp Med. 1973 Mar 1;137(3):821-37. doi: 10.1084/jem.137.3.821.
Abstract
An experimental model system was developed to study the differentiation of thymus-derived (T) cells from progenitors in bone marrow. In this system transplantation of bone marrow cells depleted of T cells gave rise to T cells in the spleens of irradiated recipients within 15 days of transplantation. Thus, normal bone marrow contains a class of cells that are progeniotrs of T cells (PT cells). PT cells are different from T cells since PT cells are incapable of responding to alloantigen, are theta resistant, and band in a lighter density region than do T cells. The density profile of PT cells is different from that of hematopoietic stem cells (CFU-S); PT cells band in a denser region of the gradient than do CFU-S.
摘要
为了研究骨髓中祖细胞向胸腺来源（T）细胞的分化，开发了一种实验模型系统。在该系统中，去除T细胞的骨髓细胞移植后，在移植后15天内，受照射受体的脾脏中产生了T细胞。因此，正常骨髓中含有一类细胞，即T细胞祖细胞（PT细胞）。PT细胞与T细胞不同，因为PT细胞不能对同种异体抗原作出反应，具有θ抗性，并且在密度比T细胞更轻的区域形成条带。PT细胞的密度分布与造血干细胞（CFU-S）不同；PT细胞在梯度密度的较密区域形成条带，而CFU-S则不然。
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本文引用的文献
1
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Transplantation. 1964 May;2:393-404. doi: 10.1097/00007890-196405000-00009.
2
A direct measurement of the radiation sensitivity of normal mouse bone marrow cells.正常小鼠骨髓细胞辐射敏感性的直接测量。
Radiat Res. 1961 Feb;14:213-22.
3
Immunological aspects of homo- and heterologous bone marrow transplantation in irradiated animals.
J Cell Physiol Suppl. 1957 Dec;50(Suppl 1):139-56. doi: 10.1002/jcp.1030500410.
4
Cytological identification of radiation-chimaeras.辐射嵌合体的细胞学鉴定。
Nature. 1956 Mar 10;177(4506):452-4. doi: 10.1038/177452a0.
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The mitotic response of thymus-derived cells to antigenic stimulus.胸腺来源细胞对抗抗原刺激的有丝分裂反应。
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Ser Haematol. 1972;5(2):22-36.
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Lymphocytes and hemic stem cells.
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J Immunol. 1970 Sep;105(3):719-29.
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