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小鼠骨髓中前体细胞向胸腺来源细胞的分化。

Differentiation of thymus-derived cells from precursors in mouse bone marrow.

作者信息

el-Arini M O, Osoba D

出版信息

J Exp Med. 1973 Mar 1;137(3):821-37. doi: 10.1084/jem.137.3.821.

DOI:10.1084/jem.137.3.821
PMID:4266014
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2139385/
Abstract

An experimental model system was developed to study the differentiation of thymus-derived (T) cells from progenitors in bone marrow. In this system transplantation of bone marrow cells depleted of T cells gave rise to T cells in the spleens of irradiated recipients within 15 days of transplantation. Thus, normal bone marrow contains a class of cells that are progeniotrs of T cells (PT cells). PT cells are different from T cells since PT cells are incapable of responding to alloantigen, are theta resistant, and band in a lighter density region than do T cells. The density profile of PT cells is different from that of hematopoietic stem cells (CFU-S); PT cells band in a denser region of the gradient than do CFU-S.

摘要

为了研究骨髓中祖细胞向胸腺来源（T）细胞的分化，开发了一种实验模型系统。在该系统中，去除T细胞的骨髓细胞移植后，在移植后15天内，受照射受体的脾脏中产生了T细胞。因此，正常骨髓中含有一类细胞，即T细胞祖细胞（PT细胞）。PT细胞与T细胞不同，因为PT细胞不能对同种异体抗原作出反应，具有θ抗性，并且在密度比T细胞更轻的区域形成条带。PT细胞的密度分布与造血干细胞（CFU-S）不同；PT细胞在梯度密度的较密区域形成条带，而CFU-S则不然。

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1
Differentiation of thymus-derived cells from precursors in mouse bone marrow.小鼠骨髓中前体细胞向胸腺来源细胞的分化。
J Exp Med. 1973 Mar 1;137(3):821-37. doi: 10.1084/jem.137.3.821.
2
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引用本文的文献

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3
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本文引用的文献

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THE SELECTIVE ELIMINATION OF IMMUNOLOGICALLY COMPETENT CELLS FROM BONE MARROW AND LYMPHATIC CELL MIXTURES. I. EFFECT OF STORAGE AT 4 C.
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Homogeneity of antibody-producing cells as analysed by their buoyant density in gradients of Ficoll.通过抗体产生细胞在Ficoll梯度中的浮力密度分析其同质性。
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7
Initiation of antibody production to sheep erythrocytes in vitro: replacement of the requirement for T-cells with a cell-free factor isolated from cultures of lymphoid cells.体外针对绵羊红细胞的抗体产生起始：用从淋巴细胞培养物中分离出的无细胞因子替代对T细胞的需求。
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Density distributions of marrow cells from mouse and man.小鼠和人类骨髓细胞的密度分布。
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Lymphocytes and hemic stem cells.
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Differentiation of rosette-forming cells from myeloid stem cells.从髓系干细胞分化出玫瑰花结形成细胞。
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