Maxie M G, Valli V E, Robinson G A, Truscott R B, McSherry B J
Can J Comp Med. 1974 Oct;38(4):347-66.
The clearance of (51)Cr-labelled Pseudomonas endotoxin from the blood was studied in calves in a nontolerant and in an endotoxin-tolerant state. Calves were rendered tolerant to the toxic effects of the endotoxin by four daily intravenous injections of endotoxin at the dose rate of 5 microg/kg body weight. Clearance of a small amount of (51)Cr-endotoxin from the blood of nontolerant calves was almost complete within three minutes of injection and was not significantly faster in tolerant calves. The lungs and liver were the major organs involved in clearance of endotoxin from the blood. The (51)Cr label was slowly excreted by the kidneys. Neither platelets nor leukocytes were demonstrated to participate in endotoxin clearance in calves. (51)CrCl(3) was injected into control calves. Relative to the distribution and loss of labelled endotoxin, the (51)CrCl(3) was cleared slowly from the blood, was distributed uniformly throughout the body and was excreted rapidly.
在处于非耐受状态和内毒素耐受状态的犊牛中研究了（51）铬标记的假单胞菌内毒素从血液中的清除情况。通过以5微克/千克体重的剂量率每日静脉注射内毒素四次，使犊牛对内毒素的毒性作用产生耐受。在注射后三分钟内，非耐受犊牛血液中少量（51）铬-内毒素的清除几乎完成，而耐受犊牛的清除速度并未显著加快。肺和肝是参与从血液中清除内毒素的主要器官。（51）铬标记物由肾脏缓慢排泄。在犊牛中，未证明血小板和白细胞参与内毒素清除。将（51）氯化铬注入对照犊牛体内。相对于标记内毒素的分布和损失，（51）氯化铬从血液中清除缓慢，在全身均匀分布，并迅速排泄。
