Takano K, Warren J, Jensen K E, Neal A L
J Bacteriol. 1965 Dec;90(6):1542-7. doi: 10.1128/jb.90.6.1542-1547.1965.
Takano, Kouichi (Chas. Pfizer & Co., Inc., Terre Haute, Ind.), Joel Warren, Keith E. Jensen, and Alan L. Neal. Nucleic acid resistance to viral infection. J. Bacteriol. 90:1542-1547. 1965.-Administration of nonviral nucleic acids to mice increased their resistance to a subsequent infection with influenza or encephalomyocarditis viruses. Injection of ribonucleic acid or deoxyribonucleic acid by peripheral routes did not modify susceptibility to intranasal infection. Lung tissue extracts from animals previously treated with yeast nucleic acid inhibited the growth of vaccinia and influenza viruses. The protective effect of exogenous nucleic acids persisted in mice for several days, but gradually diminished to undetectable levels.
高野浩一（美国印第安纳州特雷霍特市辉瑞公司）、乔尔·沃伦、基思·E·詹森和艾伦·L·尼尔。核酸对病毒感染的抗性。《细菌学杂志》90:1542 - 1547。1965年。给小鼠施用非病毒核酸可增强其对随后流感或脑心肌炎病毒感染的抗性。经外周途径注射核糖核酸或脱氧核糖核酸不会改变对鼻内感染的易感性。先前用酵母核酸处理过的动物的肺组织提取物可抑制牛痘病毒和流感病毒的生长。外源性核酸的保护作用在小鼠体内持续数天，但逐渐减弱至无法检测的水平。
