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相似文献

1
Absorption of antigens after oral immunisation and the simultaneous induction of specific systemic tolerance.口服免疫后抗原的吸收及特异性全身耐受性的同时诱导。
Gut. 1979 Feb;20(2):121-5. doi: 10.1136/gut.20.2.121.
2
Genetic differences in immune exclusion and partial tolerance to ingested antigens.免疫排斥及对摄入抗原的部分耐受性中的基因差异。
Clin Exp Immunol. 1983 Jun;52(3):678-84.
3
In vivo tolerization of Th1 lymphocytes following a single feeding with ovalbumin: anergy in the absence of suppression.用卵清蛋白单次喂食后Th1淋巴细胞的体内耐受：无抑制情况下的无反应性
Eur J Immunol. 1994 Sep;24(9):1974-81. doi: 10.1002/eji.1830240906.
4
Oral tolerance to ovalbumin in mice: effect of some parameters on the induction and persistence of the suppression of systemic IgE and IgG antibody responses.小鼠对卵清蛋白的口服耐受：某些参数对系统性IgE和IgG抗体反应抑制的诱导及持续的影响
Adv Exp Med Biol. 1995;371B:1229-34.
5
Oral tolerance to ovalbumin in mice: studies of chemically modified and 'biologically filtered' antigen.小鼠对卵清蛋白的口服耐受：化学修饰和“生物过滤”抗原的研究
Immunology. 1986 Apr;57(4):627-30.
6
Mucosal suppression by oral pre-treatment with ovalbumin and its conversion into stimulation when ovalbumin was conjugated to cholera toxin or its B subunit.用卵清蛋白进行口服预处理引起的黏膜抑制，以及当卵清蛋白与霍乱毒素或其B亚基结合时这种抑制转变为刺激作用。
Adv Exp Med Biol. 1995;371B:1251-5.
7
Importance of gastrointestinal ingestion and macromolecular antigens in the vein for oral tolerance induction.胃肠道摄入和静脉内大分子抗原在诱导口服耐受中的重要性。
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8
Decrease in susceptibility to oral tolerance induction and occurrence of oral immunization to ovalbumin in 20-38-week-old mice. The effect of interval between oral exposures and rate of antigen intake in the oral immunization.20至38周龄小鼠对口服耐受诱导的易感性降低及对卵清蛋白口服免疫的发生。口服免疫中口服暴露间隔和抗原摄取率的影响。
Immunology. 1993 Jan;78(1):147-51.
9
Suppression of an established DTH response to ovalbumin in mice by feeding antigen after immunization.免疫后通过喂食抗原抑制小鼠对卵清蛋白已建立的迟发型超敏反应。
Immunology. 1988 May;64(1):135-9.
10
[Tolerance induction by the peroral administration of protein antigens].[经口给予蛋白质抗原诱导耐受性]
Zh Mikrobiol Epidemiol Immunobiol. 1984 Aug(8):83-8.

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Oral tolerance to prevent anti-drug antibody formation in protein replacement therapies.口服耐受以预防蛋白质替代疗法中的抗药物抗体形成。
Cell Immunol. 2022 Dec;382:104641. doi: 10.1016/j.cellimm.2022.104641. Epub 2022 Nov 14.
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The development and role of microbial-host interactions in gut mucosal immune development.微生物与宿主相互作用在肠道黏膜免疫发育中的发展及作用
J Anim Sci Biotechnol. 2017 Jan 26;8:12. doi: 10.1186/s40104-016-0138-0. eCollection 2017.
3
A mechanistic, multiscale mathematical model of immunogenicity for therapeutic proteins: part 2-model applications.一种治疗性蛋白免疫原性的机理、多尺度数学模型：第 2 部分-模型应用。
CPT Pharmacometrics Syst Pharmacol. 2014 Sep 3;3(9):e134. doi: 10.1038/psp.2014.31.
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The twenty-year story of a plant-based vaccine against hepatitis B: stagnation or promising prospects?一种基于植物的乙肝疫苗的二十年历程：停滞不前还是前景光明？
Int J Mol Sci. 2013 Jan 21;14(1):1978-98. doi: 10.3390/ijms14011978.
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Phenotypic characterization of cells participating in transport of prion protein aggregates across the intestinal mucosa of sheep.参与朊病毒蛋白聚集物穿过绵羊肠道黏膜运输的细胞的表型特征。
Prion. 2012 Jul 1;6(3):261-75. doi: 10.4161/pri.19215.
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Low-dose oral immunization with lyophilized tissue of herbicide-resistant lettuce expressing hepatitis B surface antigen for prototype plant-derived vaccine tablet formulation.以表达乙型肝炎表面抗原的耐除草剂生菜冻干组织进行低剂量口服免疫，以制备原型植物源疫苗片剂。
J Appl Genet. 2011 May;52(2):125-36. doi: 10.1007/s13353-010-0001-5. Epub 2010 Nov 23.
7
Plasmacytoid dendritic cells mediate oral tolerance.浆细胞样树突状细胞介导口服耐受。
Immunity. 2008 Sep 19;29(3):464-75. doi: 10.1016/j.immuni.2008.06.017.
8
Mesenteric lymph nodes at the center of immune anatomy.肠系膜淋巴结位于免疫解剖结构的中心。
J Exp Med. 2006 Mar 20;203(3):497-500. doi: 10.1084/jem.20060227. Epub 2006 Mar 13.
9
Lamina propria lymphocytes produce interferon-gamma and develop suppressor activity in response to lactoglobulin.固有层淋巴细胞产生γ干扰素，并在对乳球蛋白的反应中产生抑制活性。
Dig Dis Sci. 2001 Mar;46(3):661-7. doi: 10.1023/a:1005684123481.
10
Visualizing the T-cell response elicited by oral administration of soluble protein antigen.可视化口服可溶性蛋白抗原引发的T细胞反应。
Immunology. 1999 Aug;97(4):565-72. doi: 10.1046/j.1365-2567.1999.00824.x.

本文引用的文献

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Preparation of iodine-131 labelled human growth hormone of high specific activity.高比活度碘-131标记人生长激素的制备
Nature. 1962 May 5;194:495-6. doi: 10.1038/194495a0.
2
Selective IgA deficiency: presentation of 30 cases and a review of the literature.选择性IgA缺乏症：30例病例报告及文献综述
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3
Resistance of rabbit secretory IgA to proteolysis.兔分泌型免疫球蛋白A对蛋白水解的抗性
Biochim Biophys Acta. 1971 May 25;236(2):440-9. doi: 10.1016/0005-2795(71)90224-8.
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Intestinal uptake of macromolecules. II. Effect of parenteral immunization.大分子的肠道摄取。II. 胃肠外免疫的影响。
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5
Intestinal uptake of macromolecules: effect of oral immunization.肠道对大分子的摄取：口服免疫的影响
Science. 1972 Aug 18;177(4049):608-10. doi: 10.1126/science.177.4049.608.
6
[Immunological responses to oraly ingested antigens (author's transl)].对口服抗原的免疫反应（作者译）
Ann Immunol (Paris). 1973 May;124(2):253-72.
7
The induction of tolerance to a soluble protein antigen by oral administration.通过口服诱导对可溶性蛋白质抗原的耐受性。
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8
Regulation of homocytotropic antibody formation in the rat. VI. Inhibitory effect of thymocytes on the homocytotropic antibody response.大鼠中亲同种细胞抗体形成的调节。VI. 胸腺细胞对亲同种细胞抗体反应的抑制作用。
J Immunol. 1971 Dec;107(6):1682-9.
9
Interference of oral immunization with the intestinal absorption of heterologous albumin.口服免疫对异源白蛋白肠道吸收的干扰。
Eur J Immunol. 1974 Oct;4(10):701-4. doi: 10.1002/eji.1830041013.
10
Proteolytic degradation of exocrine and serum immunoglobulins.外分泌和血清免疫球蛋白的蛋白水解降解
J Clin Invest. 1970 Jul;49(7):1374-80. doi: 10.1172/JCI106354.

口服免疫后抗原的吸收及特异性全身耐受性的同时诱导。

Absorption of antigens after oral immunisation and the simultaneous induction of specific systemic tolerance.

作者信息

Swarbrick E T, Stokes C R, Soothill J F

出版信息

Gut. 1979 Feb;20(2):121-5. doi: 10.1136/gut.20.2.121.

DOI:10.1136/gut.20.2.121
PMID:428823
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1419457/
Abstract

Antigenic proteins may be absorbed intact. We report here results from in vivo experiments in mice showing that the prior feeding of protein antigen may reduce the subsequent absorption of that antigen without altering its elimination from the circulation. This may be a function of local immunity. We have also shown that the same feeding regime can paradoxically induce a state of systemic tolerance and suggest that the two phenomena contribute to the safe handling of these antigens.

摘要

抗原性蛋白质可能会完整地被吸收。我们在此报告在小鼠体内进行的实验结果，这些结果表明，预先喂食蛋白质抗原可能会减少该抗原随后的吸收，而不会改变其从循环系统中的清除。这可能是局部免疫的一种作用。我们还表明，相同的喂食方式可能会反常地诱导全身耐受状态，并认为这两种现象有助于安全处理这些抗原。