口服免疫后抗原的吸收及特异性全身耐受性的同时诱导。
Absorption of antigens after oral immunisation and the simultaneous induction of specific systemic tolerance.
作者信息
Swarbrick E T, Stokes C R, Soothill J F
出版信息
Gut. 1979 Feb;20(2):121-5. doi: 10.1136/gut.20.2.121.
Abstract
Antigenic proteins may be absorbed intact. We report here results from in vivo experiments in mice showing that the prior feeding of protein antigen may reduce the subsequent absorption of that antigen without altering its elimination from the circulation. This may be a function of local immunity. We have also shown that the same feeding regime can paradoxically induce a state of systemic tolerance and suggest that the two phenomena contribute to the safe handling of these antigens.
摘要
抗原性蛋白质可能会完整地被吸收。我们在此报告在小鼠体内进行的实验结果，这些结果表明，预先喂食蛋白质抗原可能会减少该抗原随后的吸收，而不会改变其从循环系统中的清除。这可能是局部免疫的一种作用。我们还表明，相同的喂食方式可能会反常地诱导全身耐受状态，并认为这两种现象有助于安全处理这些抗原。
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Preparation of iodine-131 labelled human growth hormone of high specific activity.高比活度碘-131标记人生长激素的制备
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The induction of tolerance to a soluble protein antigen by oral administration.通过口服诱导对可溶性蛋白质抗原的耐受性。
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Interference of oral immunization with the intestinal absorption of heterologous albumin.口服免疫对异源白蛋白肠道吸收的干扰。
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Proteolytic degradation of exocrine and serum immunoglobulins.外分泌和血清免疫球蛋白的蛋白水解降解
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