S-腺苷甲硫氨酸在酵母蛋氨酸生物合成中的作用。
Role of S-adenosylmethionine in methionine biosynthesis in yeast.
作者信息
Botsford J L, Parks L W
出版信息
J Bacteriol. 1967 Oct;94(4):966-71. doi: 10.1128/jb.94.4.966-971.1967.
Abstract
Extracts of Saccharomyces cerevisiae were used to develop a cell-free system capable of converting the beta-carbon of serine into the methyl group of methionine. No requirement for either S-adenosylmethionine or S-adenosylhomocysteine could be demonstrated for net methionine biosynthesis. Growth of the cells in B(12) did not affect the reaction. The mechanism for the methylation of homocysteine in yeast appears to be similar to the non-B(12) system in Escherichia coli.
摘要
酿酒酵母提取物被用于开发一种无细胞系统，该系统能够将丝氨酸的β-碳转化为甲硫氨酸的甲基。对于甲硫氨酸的净生物合成，未证明需要S-腺苷甲硫氨酸或S-腺苷高半胱氨酸。细胞在维生素B12中生长不影响该反应。酵母中高半胱氨酸甲基化的机制似乎与大肠杆菌中的非维生素B12系统相似。
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