Sloan J M, Buchanan K D, McFarland R J, Titterington P, Sandford J C
J Clin Pathol. 1979 Mar;32(3):201-7. doi: 10.1136/jcp.32.3.201.
To determine the effect of varying degrees of gastritis on the distribution of immuno-reactive gastrin cells 38 partial gastrectomy specimens have been studied. Routinely stained histological sections of mucosa were compared with serial and adjacent sections stained by specific immunohistochemistry using peroxidase and fluorescent techniques. While chronic superficial gastritis had no obvious effect, mild atrophic gastritis was associated with an uneven distribution of gastrin cells which became more marked with increasing severity of gastritis. In the region of intestinal metaplasia gastrin cells were almost totally absent. Small numbers of gastrin cells were found within areas of pseudopyloric metaplasia in the fundus, a region where those cells are not normally seen. Similarly, gastrin cells were detected within regenerative gastric polypi in both antrum and fundus.
为了确定不同程度的胃炎对免疫反应性胃泌素细胞分布的影响，我们研究了38例部分胃切除术标本。将常规染色的黏膜组织学切片与使用过氧化物酶和荧光技术进行特异性免疫组织化学染色的连续及相邻切片进行比较。虽然慢性浅表性胃炎没有明显影响，但轻度萎缩性胃炎与胃泌素细胞分布不均有关，且随着胃炎严重程度的增加，这种不均现象变得更加明显。在肠化生区域，胃泌素细胞几乎完全缺失。在胃底假幽门化生区域发现了少量胃泌素细胞，而该区域通常不会出现这些细胞。同样，在胃窦和胃底的再生性胃息肉内也检测到了胃泌素细胞。
