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1
A simple index for the measurement of the runting syndrome and its use in the study of the influence of the gut flora in its production.一种用于测量发育迟缓综合征的简单指标及其在研究肠道菌群对其产生影响中的应用。
Immunology. 1968 Aug;15(2):237-45.
2
The pathology of murine runting and its modification by neomycin sulphate gavages.小鼠发育不良的病理学及其通过硫酸新霉素灌胃的改变。
Immunology. 1968 Aug;15(2):247-62.
3
The murine runting syndrome and neoplasia.小鼠发育不良综合征与肿瘤形成
Immunology. 1969 Jun;16(6):693-7.
4
PATHOGENESIS OF THE POST-NEONATAL THYMECTOMY WASTING SYNDROME.新生儿期后胸腺切除致消瘦综合征的发病机制
Nature. 1964 Oct 10;204:151-5. doi: 10.1038/204151a0.
5
Post-thymectomy wasting disease and intestinal bacterial flora.胸腺切除术后消耗性疾病与肠道菌群
Arch Pathol. 1969 Jan;87(1):29-34.
6
Possible role of endotoxemia during immunologic imbalance.内毒素血症在免疫失衡过程中的可能作用。
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7
Reversal of post-thymectomy wasting disease in mice by multiple thymus grafts.通过多次胸腺移植逆转小鼠胸腺切除术后的消瘦病
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8
Immunological assessment of mice with chronic jaundice and runting induced by reovirus 3.呼肠孤病毒3诱导的慢性黄疸和发育不良小鼠的免疫学评估
Br J Exp Pathol. 1973 Jun;54(3):329-45.
9
Runting syndromes, autoimmunity, and neoplasia.发育迟缓综合征、自身免疫和肿瘤形成。
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10
Graft-versus-host reactions induced by transplantation of parental strain thymus in neonatally thymectomized F1 hybrid mice.在新生期切除胸腺的F1杂交小鼠中，亲本品系胸腺移植所诱导的移植物抗宿主反应。
Transplantation. 1968 Jul;6(4):514-23. doi: 10.1097/00007890-196807000-00002.

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Inflammatory bowel disease in C.B-17 scid mice reconstituted with the CD45RBhigh subset of CD4+ T cells.用CD4⁺T细胞的CD45RB高表达亚群重建的C.B-17重度联合免疫缺陷小鼠中的炎症性肠病
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Estradiol-induced wasting syndrome in conventionally reared and germ-free mice.常规饲养和无菌小鼠中雌二醇诱导的消瘦综合征
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3
Hormones and the immunological capacity. V. Modification of growth hormone-producing cells in the adenohypophysis of neonatally thymectomized germ-free mice: an electron microscopical study.激素与免疫能力。V. 新生期胸腺切除的无菌小鼠腺垂体中生长激素分泌细胞的改变：一项电子显微镜研究
Clin Exp Immunol. 1971 Dec;9(6):889-901.
4
Laminar airflow protection in bone marrow transplantation.骨髓移植中的层流气流保护
Appl Microbiol. 1971 Feb;21(2):209-16. doi: 10.1128/am.21.2.209-216.1971.
5
Hormones, thymus and lymphocyte functions.激素、胸腺与淋巴细胞功能。
Experientia. 1972 Nov 15;28(11):1385-9. doi: 10.1007/BF01965362.
6
Infectious complications in bone marrow transplant patients.骨髓移植患者的感染性并发症
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7
Reovirus pathogenesis and the identity of REO3MH.呼肠孤病毒发病机制与REO3MH的特性
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8
The murine runting syndrome and neoplasia.小鼠发育不良综合征与肿瘤形成
Immunology. 1969 Jun;16(6):693-7.
9
The pathology of murine runting and its modification by neomycin sulphate gavages.小鼠发育不良的病理学及其通过硫酸新霉素灌胃的改变。
Immunology. 1968 Aug;15(2):247-62.
10
Exercise and the immune response.运动与免疫反应。
Sports Med. 1988 Apr;5(4):248-67. doi: 10.2165/00007256-198805040-00004.

本文引用的文献

1
Runt disease.侏儒病
Br Med J. 1962 Jan 20;1(5272):129-35 contd. doi: 10.1136/bmj.1.5272.129.
2
The weight-gain assay for runt disease in mice.小鼠发育不全病的体重增加测定法。
Ann N Y Acad Sci. 1960 May 31;87:445-51. doi: 10.1111/j.1749-6632.1960.tb23211.x.
3
Studies on mouse leukaemia. Leukaemogenesis by cell-free filtrates inoculated in newborn and adult mice.小鼠白血病研究。通过接种于新生和成年小鼠的无细胞滤液诱导白血病发生。
Br J Cancer. 1960 Mar;14(1):83-92. doi: 10.1038/bjc.1960.10.
4
SOME SIMILARITIES BETWEEN THE NEONATAL THYMECTOMY SYNDROME AND GRAFT-VERSUS-HOST DISEASE.新生儿胸腺切除综合征与移植物抗宿主病之间的一些相似之处。
J Reticuloendothel Soc. 1964 Dec;1:369-92.
5
THE ABSENCE OF WASTING IN THYMECTOMIZED GERMFREE (AXENIC) MICE.胸腺切除的无菌（单菌）小鼠无消瘦现象。
Proc Soc Exp Biol Med. 1964 Oct;117:237-9. doi: 10.3181/00379727-117-29545.
6
EXPERIMENTAL RUNT DISEASE IN MICE CAUSED BY SALMONELLA TYPHIMURIUM, VAR. COPENHAGEN.鼠伤寒沙门氏菌哥本哈根变种引起的小鼠实验性朗特病
J Exp Med. 1964 Sep 1;120(3):375-87. doi: 10.1084/jem.120.3.375.
7
MURINE INFECTION WITH REOVIRUS: I. PATHOLOGY OF THE ACUTE PHASE.呼肠孤病毒感染小鼠：I. 急性期病理学
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8
Increased sensitivity to bacterial endotoxin of F-1 hybrid mice undergoing graft-versus-host reaction.发生移植物抗宿主反应的F-1杂种小鼠对细菌内毒素的敏感性增加。
Nature. 1961 Jun 17;190:1122. doi: 10.1038/1901122a0.
9
The effect of Mycobacterium tuberculosis (BCG) infection on the resistance of mice to bacterial endotoxin and Salmonella enteritidis infection.结核分枝杆菌（卡介苗）感染对小鼠抵抗细菌内毒素和肠炎沙门氏菌感染能力的影响。
Br J Exp Pathol. 1959 Jun;40(3):281-90.
10
The impact on the developing embryo and newborn animal of adult homologous cells.成年同源细胞对发育中胚胎和新生动物的影响。
Acta Pathol Microbiol Scand. 1957;40(6):480-500.

一种用于测量发育迟缓综合征的简单指标及其在研究肠道菌群对其产生影响中的应用。

A simple index for the measurement of the runting syndrome and its use in the study of the influence of the gut flora in its production.

作者信息

Keast D

出版信息

Immunology. 1968 Aug;15(2):237-45.

PMID:4299786
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1409448/
Abstract

This communication describes a simple, sensitive index for the measurement of the runting syndrome. Evidence is presented that the bacterial flora of the gut and endotoxin derived therefrom may play a role in induction of the runting syndrome. There was no evidence of bacterial invasion of runted animals. Neomycin sulphate given by gavage reduced the intensity of the runting syndrome. Furthermore, bacterial endotoxin produced runts sharing many of the features found in runts produced by the graft--host reaction, cortisone acetate, bacterial vaccine, neonatal reovirus 3 infection and neonatal thymectomy.

摘要

本通讯描述了一种用于测量发育迟缓综合征的简单、灵敏指标。有证据表明，肠道菌群及其衍生的内毒素可能在发育迟缓综合征的诱发中起作用。没有证据表明发育迟缓的动物存在细菌入侵。经口灌喂硫酸新霉素可降低发育迟缓综合征的严重程度。此外，细菌内毒素导致的发育迟缓动物具有许多与移植物-宿主反应、醋酸可的松、细菌疫苗、新生鼠呼肠孤病毒3感染和新生鼠胸腺切除所导致的发育迟缓动物相同的特征。