一种用于测量发育迟缓综合征的简单指标及其在研究肠道菌群对其产生影响中的应用。
A simple index for the measurement of the runting syndrome and its use in the study of the influence of the gut flora in its production.
作者信息
Keast D
出版信息
Immunology. 1968 Aug;15(2):237-45.
Abstract
This communication describes a simple, sensitive index for the measurement of the runting syndrome. Evidence is presented that the bacterial flora of the gut and endotoxin derived therefrom may play a role in induction of the runting syndrome. There was no evidence of bacterial invasion of runted animals. Neomycin sulphate given by gavage reduced the intensity of the runting syndrome. Furthermore, bacterial endotoxin produced runts sharing many of the features found in runts produced by the graft--host reaction, cortisone acetate, bacterial vaccine, neonatal reovirus 3 infection and neonatal thymectomy.
摘要
本通讯描述了一种用于测量发育迟缓综合征的简单、灵敏指标。有证据表明，肠道菌群及其衍生的内毒素可能在发育迟缓综合征的诱发中起作用。没有证据表明发育迟缓的动物存在细菌入侵。经口灌喂硫酸新霉素可降低发育迟缓综合征的严重程度。此外，细菌内毒素导致的发育迟缓动物具有许多与移植物-宿主反应、醋酸可的松、细菌疫苗、新生鼠呼肠孤病毒3感染和新生鼠胸腺切除所导致的发育迟缓动物相同的特征。
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本文引用的文献
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