Takeda H, Kiriyama S
J Nutr. 1979 Mar;109(3):388-96. doi: 10.1093/jn/109.3.388.
The mechanism(s) by which dietary fiber (DF) exerts beneficial effects on the growth of weanling rats fed toxic doses of amaranth (Food & C Red No. 2) was investigated. When crude DF (GDF) prepared from the roots of edible burdock (Arctium lappa L.) were added at graded levels to a purified basal diet supplemented with amaranth (control), growth was improved with increaseing GDF level up to and above that of the basal diet-fed group. The correlation equation obtained between the dietary percentage level of GDF (X) and the protective activity (Y) expressed as (difference in body weight gains between rats fed test and control diets) X 100/(difference in body weight gains between rats fed basal and control diets) was Y = 32.6 + 86.9 logX (r = 0.98). The comparative activities at the 5% level of various DF prepared from GDF decreased in the order of holocellulose, neutral-detergent fiber, GDF, crude fiber and acid-detergent fiber. Cellulose from cotton fiber had no activity. The activity was intimately related to their water-holding capacity (WHC) and settling volume in water (SV) (f = 0.90 and 0.96, respectively), but not to the capacity to bind amaranth. The correlation showed a saturation phenomenon quite similar to the equation described above in respect of GDF level. At the 10% level, even cellulose which has a low SV, showed protective activity similar to that of 3% GDF. From these and other results, it was concluded that the protective activity of various DF mainly depends on their physical properties such as SV or WHC.
研究了膳食纤维（DF）对喂食有毒剂量苋菜红（食用色素红2号）的断奶大鼠生长产生有益影响的机制。将从牛蒡（Arctium lappa L.）根中制备的粗膳食纤维（GDF）以分级水平添加到补充了苋菜红的纯化基础日粮（对照）中，随着GDF水平的增加，生长得到改善，直至达到并超过基础日粮喂养组的水平。GDF日粮百分比水平（X）与保护活性（Y）之间的相关方程表示为（喂食试验日粮和对照日粮的大鼠体重增加差异）×100/（喂食基础日粮和对照日粮的大鼠体重增加差异），即Y = 32.6 + 86.9 logX（r = 0.98）。由GDF制备的各种DF在5%水平下的相对活性从高到低依次为全纤维素、中性洗涤纤维、GDF、粗纤维和酸性洗涤纤维。棉纤维中的纤维素没有活性。该活性与它们的持水能力（WHC）和在水中的沉降体积（SV）密切相关（分别为f = 0.90和0.96），但与结合苋菜红的能力无关。该相关性显示出与上述关于GDF水平的方程非常相似的饱和现象。在10%水平下，即使是SV较低的纤维素也表现出与3% GDF相似的保护活性。从这些及其他结果可以得出结论，各种DF的保护活性主要取决于它们的物理性质，如SV或WHC。
