大肠杆菌K-12的D-丝氨酸脱氨酶系统中的分解代谢物阻遏
Catabolite repression in the D-serine deaminase system of Escherichia coli K-12.
作者信息
McFall E, Bloom F R
出版信息
J Bacteriol. 1971 Jan;105(1):241-8. doi: 10.1128/jb.105.1.241-248.1971.
Abstract
The induced synthesis of d-serine deaminase in Escherichia coli is subject to three catabolic effects: inhibition on inducer uptake, transient repression, and catabolite repression. Inhibition on d-serine uptake is not significant at the d-serine concentration normally used for induction. Transient repression and catabolite repression of d-serine deaminase synthesis are abolished by mutations in dsdCy, which appears to be an operator locus. The decline in the rate of constitutive synthesis observed in dsdCx mutants growing with glycerol as carbon source at temperatures above 37 C is due to catabolite repression. The low level of constitutivity at 37 C and the partial cis dominance of dsdCx mutants are not artifacts of catabolite repression. It is suggested that a product of one of the genes of the dsd operon may regulate the expression of the operon.
摘要
大肠杆菌中d -丝氨酸脱氨酶的诱导合成受到三种分解代谢效应的影响：对诱导物摄取的抑制、短暂阻遏和分解代谢物阻遏。在通常用于诱导的d -丝氨酸浓度下，对d -丝氨酸摄取的抑制作用不显著。dsdCy基因发生突变可消除d -丝氨酸脱氨酶合成的短暂阻遏和分解代谢物阻遏，dsdCy似乎是一个操纵基因位点。在温度高于37℃以甘油作为碳源生长的dsdCx突变体中，组成型合成速率的下降是由于分解代谢物阻遏。37℃时组成型表达水平较低以及dsdCx突变体的部分顺式显性并非分解代谢物阻遏的假象。有人提出，dsd操纵子中一个基因的产物可能调节该操纵子的表达。
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