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小肠结肠炎耶尔森菌耐热肠毒素对兔回肠离子转运及环鸟苷酸3',5'-单磷酸代谢的影响

Effects of heat-stable enterotoxin of Yersinia enterocolitica on ion transport and cyclic guanosine 3',5'-monophosphate metabolism in rabbit ileum.

作者信息

Rao M C, Guandalini S, Laird W J, Field M

出版信息

Infect Immun. 1979 Dec;26(3):875-8. doi: 10.1128/iai.26.3.875-878.1979.

DOI:10.1128/iai.26.3.875-878.1979
PMID:43292
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC414701/
Abstract

Strains of Yersinia enterocolitica produce a heat-stable enterotoxin which is positive in the suckling mouse bioassay. Partial purification by a procedure previously worked out for heat-stable Escherichia coli enterotoxin yielded a substance which increases particulate guanylate cyclase activity and short-circuit current and inhibits active Cl-absorption in rabbit ileal mucosa. These effects of Y. enterocolitica enterotoxin are similar to those of heat-stable E. coli enterotoxin, suggesting a common mechanism of action.

摘要

小肠结肠炎耶尔森菌菌株产生一种在乳鼠生物测定中呈阳性的热稳定肠毒素。通过先前为热稳定大肠杆菌肠毒素设计的程序进行部分纯化,得到了一种物质,该物质可增加颗粒型鸟苷酸环化酶活性和短路电流,并抑制兔回肠黏膜中的主动氯吸收。小肠结肠炎耶尔森菌肠毒素的这些作用与热稳定大肠杆菌肠毒素的作用相似,提示存在共同的作用机制。

相似文献

1
Effects of heat-stable enterotoxin of Yersinia enterocolitica on ion transport and cyclic guanosine 3',5'-monophosphate metabolism in rabbit ileum.小肠结肠炎耶尔森菌耐热肠毒素对兔回肠离子转运及环鸟苷酸3',5'-单磷酸代谢的影响
Infect Immun. 1979 Dec;26(3):875-8. doi: 10.1128/iai.26.3.875-878.1979.
2
Comparison of the biological actions of three purified heat-stable enterotoxins: effects on ion transport and guanylate cyclase activity in rabbit ileum in vitro.三种纯化的热稳定肠毒素生物学作用的比较:对兔回肠体外离子转运和鸟苷酸环化酶活性的影响
Infect Immun. 1981 Jul;33(1):165-70. doi: 10.1128/iai.33.1.165-170.1981.
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Detection of Yersinia enterocolitica heat-stable enterotoxin by suckling mouse bioassay.通过乳鼠生物测定法检测小肠结肠炎耶尔森菌热稳定肠毒素。
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Physiologic and pharmacologic effects of glucocorticoids on ion transport across rabbit ileal mucosa in vitro.糖皮质激素对体外兔回肠黏膜离子转运的生理和药理作用。
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Active sulfate absorption in rabbit ileum: dependence on sodium and chloride and effects of agents that alter chloride transport.兔回肠中活性硫酸盐的吸收:对钠和氯的依赖性以及改变氯转运的药物的作用
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本文引用的文献

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