Rao M C, Guandalini S, Laird W J, Field M
Infect Immun. 1979 Dec;26(3):875-8. doi: 10.1128/iai.26.3.875-878.1979.
Strains of Yersinia enterocolitica produce a heat-stable enterotoxin which is positive in the suckling mouse bioassay. Partial purification by a procedure previously worked out for heat-stable Escherichia coli enterotoxin yielded a substance which increases particulate guanylate cyclase activity and short-circuit current and inhibits active Cl-absorption in rabbit ileal mucosa. These effects of Y. enterocolitica enterotoxin are similar to those of heat-stable E. coli enterotoxin, suggesting a common mechanism of action.
小肠结肠炎耶尔森菌菌株产生一种在乳鼠生物测定中呈阳性的热稳定肠毒素。通过先前为热稳定大肠杆菌肠毒素设计的程序进行部分纯化,得到了一种物质,该物质可增加颗粒型鸟苷酸环化酶活性和短路电流,并抑制兔回肠黏膜中的主动氯吸收。小肠结肠炎耶尔森菌肠毒素的这些作用与热稳定大肠杆菌肠毒素的作用相似,提示存在共同的作用机制。