小肠结肠炎耶尔森菌产生肠毒素。
Production of enterotoxin by Yersinia enterocolitica.
作者信息
Pai C H, Mors V
出版信息
Infect Immun. 1978 Mar;19(3):908-11. doi: 10.1128/iai.19.3.908-911.1978.
Abstract
Forty-three strains of Yersinia enterocolitica isolated from children with gastroenteritis and 18 laboratory strains were examined for enterotoxin production by using the infant mouse, Y1 adrenal cell, and rabbit ileal loop assay systems. All clinical isolates and seven laboratory strains were found enterotoxigenic in the infant mouse model, but none of the strains produced toxin in the Y1 adrenal cell system. One enterotoxin-producing strain was also tested by the rabbit ileal loop assay, confirming the results of the infant mouse assay. The enterotoxin was heat-stable and as active in the 6-h rabbit ileal loop as in the 18-h assay, suggesting a similarity to the heat-stable enterotoxin of Escherichia coli.
摘要
对从患肠胃炎儿童中分离出的43株小肠结肠炎耶尔森菌以及18株实验室菌株，运用幼鼠、Y1肾上腺细胞和兔回肠袢试验系统检测其肠毒素产生情况。在幼鼠模型中，所有临床分离株和7株实验室菌株均被发现具有产肠毒素性，但在Y1肾上腺细胞系统中，没有菌株产生毒素。一株产肠毒素菌株也通过兔回肠袢试验进行了检测，证实了幼鼠试验的结果。该肠毒素具有热稳定性，在6小时的兔回肠袢试验中的活性与18小时试验中的活性相同，提示其与大肠杆菌的热稳定肠毒素相似。
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