用 pactamycin 测定脊髓灰质炎病毒的基因序列。
Determination of the gene sequence of poliovirus with pactamycin.
作者信息
Summers D F, Maizel J V
出版信息
Proc Natl Acad Sci U S A. 1971 Nov;68(11):2852-6. doi: 10.1073/pnas.68.11.2852.
Abstract
By examination of the virus-specific polypeptides formed after the addition of pactamycin, an inhibitor of protein chain initiation, to infected cells, it has been possible to tentatively locate the virus coat proteins at the amino terminus of the large, virus-specific protein precursor, and, therefore, to assign the coat protein cistron to the 5' end of the RNA.
摘要
通过检测在向受感染细胞中添加蛋白质链起始抑制剂放线菌酮后形成的病毒特异性多肽，已初步确定病毒衣壳蛋白位于大型病毒特异性蛋白质前体的氨基末端，因此，可将衣壳蛋白顺反子定位到RNA的5'末端。
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本文引用的文献
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J Mol Biol. 1964 Apr;8:541-55. doi: 10.1016/s0022-2836(64)80010-3.
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Biochem Biophys Res Commun. 1970 Oct 9;41(1):1-8. doi: 10.1016/0006-291x(70)90460-2.
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