Scolnick E M, Aaronson S A, Todaro G J
Proc Natl Acad Sci U S A. 1970 Oct;67(2):1034-41. doi: 10.1073/pnas.67.2.1034.
Murine leukemia (Rauscher and Moloney strains) and sarcoma (Kirsten strain) virions, as well as the mammary tumor virus of mice, contain an RNA-dependent DNA polymerase. Optimal incorporation of deoxyribonucleoside triphosphates occurs at a critical detergent (Triton X-100) concentration (0.010-0.014%). At higher than optimal detergent concentrations the virion is seen to be disrupted and enzyme activity is lost. The virion, enzymatic activity, and newly synthesized DNA all cosediment in a sucrose gradient. Thus far the enzymatic activity has been found only in RNA viruses that have oncogenic properties.
小鼠白血病病毒（劳舍尔株和莫洛尼株）、肉瘤病毒（柯斯顿株）以及小鼠乳腺肿瘤病毒都含有一种依赖RNA的DNA聚合酶。三磷酸脱氧核糖核苷的最佳掺入发生在临界去污剂（曲拉通X-100）浓度（0.010 - 0.014%）时。当去污剂浓度高于最佳浓度时，病毒粒子会被破坏且酶活性丧失。病毒粒子、酶活性以及新合成的DNA在蔗糖梯度中都一起沉降。到目前为止，仅在具有致癌特性的RNA病毒中发现了这种酶活性。
