Kufe D, Hehlmann R, Spiegelman S
Science. 1972 Jan 14;175(4018):182-5. doi: 10.1126/science.175.4018.182.
Labeled DNA complementary to the RNA of the Rauscher leukemia virus was hybridized with RNA from the polysome fraction of human sarcomas. Eighteen out of 25 specimens contained RNA possessing homology to the RNA of the mouse leukemia virus but not to that of the unrelated viruses causing mammary tumors in mice or myeloblastosis in chickens. Further, no normal adult or fetal tissues showed significant amounts of RNA specific to mouse leukemia virus. It appears that human sarcomas contain RNA sequences homologous to those found in an agent related to a virus known to cause sarcomas in mice.
将与劳斯氏白血病病毒RNA互补的标记DNA与来自人类肉瘤多核糖体部分的RNA进行杂交。25个标本中有18个含有与小鼠白血病病毒RNA具有同源性的RNA，但与在小鼠中引起乳腺肿瘤或在鸡中引起成髓细胞增多症的无关病毒的RNA没有同源性。此外，正常的成人或胎儿组织均未显示出大量对小鼠白血病病毒特异的RNA。看来人类肉瘤含有与在一种与已知可在小鼠中引起肉瘤的病毒相关的病原体中发现的RNA序列同源的RNA序列。
