霍奇金病及其他人类淋巴瘤中与病毒相关的RNA
Viral-related RNA in Hodgkins' disease and other human lymphomas.
作者信息
Hehlmann R, Kufe D, Spiegelman S
出版信息
Proc Natl Acad Sci U S A. 1972 Jul;69(7):1727-31. doi: 10.1073/pnas.69.7.1727.
Abstract
Molecular hybridization with radioactively labeled DNA complementary to the RNA of the Rauscher leukemia virus was used to probe for homologous RNA in human lymphomas. 22 of 32 specimens contained RNA possessing homology to the RNA of the mouse leukemia virus, but not to that of the unrelated viruses causing mammary tumors in mice or myeloblastosis in chickens. Normal adult and fetal tissues failed to show significant levels of the leukemia-specific RNA. It appears that human lymphomas contain RNA sequences homologous to those found in a viral agent known to cause leukemia and lymphomas in an experimental animal. The fact that human leukemias and sarcomas also contain this type of RNA further emphasizes a remarkable similarity between the corresponding neoplasias of murine and human origin.
摘要
用与劳氏肉瘤病毒RNA互补的放射性标记DNA进行分子杂交，以探测人类淋巴瘤中的同源RNA。32个标本中有22个含有与小鼠白血病病毒RNA具有同源性的RNA，但与在小鼠中引起乳腺肿瘤或在鸡中引起成髓细胞血症的无关病毒的RNA没有同源性。正常成人和胎儿组织未显示出显著水平的白血病特异性RNA。看来人类淋巴瘤含有与在一种已知可在实验动物中引起白血病和淋巴瘤的病毒因子中发现的RNA序列同源的RNA。人类白血病和肉瘤也含有这种类型的RNA这一事实进一步强调了鼠源和人源相应肿瘤之间的显著相似性。
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