Archibold E R, Williams L S
J Bacteriol. 1972 Mar;109(3):1020-6. doi: 10.1128/jb.109.3.1020-1026.1972.
Proline- and threonine-restricted growth caused a three- to fourfold derepression of the differential rate of synthesis of the prolyl- and threonyl-transfer ribonucleic acid (tRNA) synthetases, respectively. Similarly, there was approximately a 24-fold derepression in the rate of synthesis of methionyl-tRNA synthetase during methionine restriction. Addition of the respective amino acids to such derepressed cultures resulted in a repression of synthesis of their cognate synthetases. These results support previous findings and further strengthen the idea that the formation of aminoacyl-tRNA synthetases is regulated by some mechanism which is mediated by the cognate amino acids.
脯氨酸和苏氨酸限制生长分别导致脯氨酰 - 和苏氨酰 - 转移核糖核酸（tRNA）合成酶的合成差异速率出现三到四倍的去阻遏。同样，在蛋氨酸限制期间，甲硫氨酰 - tRNA合成酶的合成速率大约有24倍的去阻遏。向这种去阻遏的培养物中添加相应的氨基酸会导致其同源合成酶的合成受到抑制。这些结果支持了先前的发现，并进一步强化了这样一种观点，即氨酰 - tRNA合成酶的形成是由某种由同源氨基酸介导的机制调控的。
