大肠杆菌和鼠伤寒沙门氏菌中甲硫氨酰 - 转移核糖核酸合成酶形成的调控。
Regulation of methionyl-transfer ribonucleic acid synthetase formation in Escherichia coli and Salmonella typhimurium.
作者信息
Archibold E R, Williams L S
出版信息
J Bacteriol. 1973 Jun;114(3):1007-13. doi: 10.1128/jb.114.3.1007-1013.1973.
Abstract
The control of methionyl-transfer ribonucleic acid (tRNA) synthetase (l-methionine: soluble RNA ligase [adenosine monophosphate]) was studied in methionyl-tRNA synthetase mutants of Escherichia coli and Salmonella typhimurium. The results of activity determinations with crude extracts indicate that this enzyme of the E. coli mutant strain possessed a reduced affinity for methionine-tRNA, whereas this enzyme of the S. typhimurium mutant exhibited a decreased affinity for l-methionine. The differential rate of methionyl-tRNA synthetase formation in these two mutants was several-fold greater than that of the respective parental strains. On the other hand, the level of in vivo aminoacylation of methionine-tRNA was only about one-third that of the parent strains. These results suggest that aminoacylation of methionine-tRNA is a necessary step in repression control of methionyl-tRNA synthetase of both E. coli and S. typhimurium strains.
摘要
在大肠杆菌和鼠伤寒沙门氏菌的甲硫氨酰 - 转运核糖核酸（tRNA）合成酶（L - 甲硫氨酸：可溶性RNA连接酶[一磷酸腺苷]）突变体中研究了该酶的调控。用粗提物进行活性测定的结果表明，大肠杆菌突变菌株的这种酶对甲硫氨酰 - tRNA的亲和力降低，而鼠伤寒沙门氏菌突变体的这种酶对L - 甲硫氨酸的亲和力降低。这两个突变体中甲硫氨酰 - tRNA合成酶形成的差异速率比各自亲本菌株的差异速率大几倍。另一方面，甲硫氨酰 - tRNA的体内氨酰化水平仅约为亲本菌株的三分之一。这些结果表明，甲硫氨酰 - tRNA的氨酰化是大肠杆菌和鼠伤寒沙门氏菌菌株中甲硫氨酰 - tRNA合成酶阻遏调控的必要步骤。
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Regulation of histidyl-transfer ribonucleic acid synthetase formation in a histidyl-transfer ribonucleic acid synthetase mutant of Salmonella typhimurium.鼠伤寒沙门氏菌组氨酰 - 转移核糖核酸合成酶突变体中组氨酰 - 转移核糖核酸合成酶形成的调控
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Regulation of synthesis of methionyl-, prolyl-, and threonyl-transfer ribonucleic acid synthetases of Escherichia coli.大肠杆菌甲硫氨酰 -、脯氨酰 - 和苏氨酰 - 转移核糖核酸合成酶合成的调控
J Bacteriol. 1972 Mar;109(3):1020-6. doi: 10.1128/jb.109.3.1020-1026.1972.
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