膦甲酸钠三钠抑制乙肝病毒核心颗粒DNA聚合酶。

Trisodium phosphonoformate inhibits hepatitis B Dane particle DNA polymerase.

作者信息

Nordenfelt E, Helgstrand E, Oberg B

出版信息

Acta Pathol Microbiol Scand B. 1979 Feb;87B(1):75-6. doi: 10.1111/j.1699-0463.1979.tb02406.x.

DOI:10.1111/j.1699-0463.1979.tb02406.x

Abstract

Evidence available indicates that the so-called Dane particles are the hepatitis virus. A DNA polymerase is associated with the core of these particles. The probability that this is the viral DNA polymerase offers the possibility of preventing hepatitis B multiplication by selective inhibition of this enzyme. This investigation reports that trisodium phosphonoformate (PFA) at low concentrations but not phosphonoacetate acid (PAA) inhitits Dane particle associated DNA polymerase.

摘要

现有证据表明，所谓的“丹麦颗粒”就是乙肝病毒。一种DNA聚合酶与这些颗粒的核心相关联。这种酶为病毒DNA聚合酶的可能性为通过选择性抑制该酶来预防乙肝病毒增殖提供了可能。本研究报告称，低浓度的磷甲酸钠（PFA）可抑制与“丹麦颗粒”相关的DNA聚合酶，而膦乙酸（PAA）则无此作用。