结核分枝杆菌菌株DT培养滤液中大量存在的一种无毒水溶性糖肽的佐剂活性。
The adjuvant activity of a non-toxic, water-soluble glycopeptide present in large quantities in the culture filtrate of Mycobacterium tuberculosis strain DT.
作者信息
Stewart-Tull D E, Shimono T, Kotani S, Kato M, Ogawa Y, Yamamura Y, Koga T, Pearson C M
出版信息
Immunology. 1975 Jul;29(1):1-15.
Abstract
A water-soluble mycobacterial glycopeptide was obtained in large quantities from the culture supernatant fluid of M. tuberculosis strain DT. This glycopeptide was strongly adjuvant-active when injected, in a water-in-oil emulsion contianing ovalbumin, into guinea-pigs. In addition, it was devoid of cord factor toxicity in mice, polyarthritogenic activity in rats and cavity stimulating activity in rabbit lungs.
摘要
从结核分枝杆菌DT菌株的培养上清液中大量获得了一种水溶性分枝杆菌糖肽。当将这种糖肽与卵清蛋白一起注射到油包水乳液中并注入豚鼠体内时，它具有很强的佐剂活性。此外，它对小鼠无索状因子毒性，对大鼠无多关节炎诱导活性，对兔肺无空洞刺激活性。
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