雪貂对流感的免疫力。II. 佐剂对免疫的影响。
Immunity to influenza in ferrets. II. Influence of adjuvants on immunization.
作者信息
Potter C W, Shore S L, McLaren C, Stuart-Harris C
出版信息
Br J Exp Pathol. 1972 Apr;53(2):168-79.
Immunization of ferrets with a single intramuscular inoculation of killed A2/Hong Kong virus did not induce serum or nasal antibody, and these animals were found to be completely susceptible to subsequent infection with virulent influenza virus A2/Hong Kong/3/68. A similar result was found for ferrets immunized with 2 inoculations of killed virus vaccine given 2 weeks apart. Ferrets immunized with killed A2/Hong Kong virus in conjunction with produced relatively low levels of serum HI antibody to A2/Hong Kong virus; when infected with virulent influenza virus, these ferrets showed a modified reaction, with a less marked febrile reaction than was observed for non-immunized animals. Immunization of ferrets with killed A2/Hong Kong virus in Freund's complete adjuvant resulted in the production of relatively high levels of serum HI antibody, but no detectable nasal antibody. These animals were shown to be partially immune to subsequent infection with virulent influenza virus. However, although the serum antibody levels of these animals following immunization was comparable to that found following infection with live virus, the degree of immunity to infection with virulent influenza virus was measurably less.
用灭活的A2/香港病毒单次肌肉注射免疫雪貂，未诱导产生血清或鼻腔抗体，并且发现这些动物对随后感染强毒力的甲型流感病毒A2/香港/3/68完全易感。对间隔2周接种2次灭活病毒疫苗的雪貂也得到了类似结果。用灭活的A2/香港病毒联合[此处原文缺失相关内容]免疫的雪貂产生的针对A2/香港病毒的血清血凝抑制（HI）抗体水平相对较低；当感染强毒力流感病毒时，这些雪貂表现出一种改变的反应，发热反应比未免疫动物观察到的要轻。用弗氏完全佐剂中的灭活A2/香港病毒免疫雪貂，导致产生相对高水平的血清HI抗体，但未检测到鼻腔抗体。这些动物显示出对随后感染强毒力流感病毒具有部分免疫力。然而，尽管这些动物免疫后的血清抗体水平与感染活病毒后的相当，但对强毒力流感病毒感染的免疫程度明显较低。
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