McLaren C, Potter C W, Jennings R
J Hyg (Lond). 1974 Dec;73(3):389-99. doi: 10.1017/s0022172400042741.
The degree of immunity due to cross-reactions between antibody to influenza virus A/Hong Kong/1/68 and A/England/42/72 was studied in ferrets. Ferrets were immunized with the viruses by either live infection or by inoculation with inactivated virus vaccines. The vaccines were given with Freund's incomplete adjuvant or were given to ferrets previously infected with influenza virus A/PR/8/34. As a result of these immunizations the animals all produced similar titres of serum HI antibody to the immunizing virus, although the degree of cross-reaction with the other virus strain was variable. After immunization the animals were challenged by infection with an A/Eng/42/72-like virus and their degree of immunity was measured. It was found that the greatest immunity was in ferrets previously infected with the homologous A/Eng/42/72 virus. Animals previously infected with A/HK/68 virus also showed a measurable degree of immunity to A/Eng/42/72 infection, and this was greater than that found in animals given inactivated virus vaccines. The immunity produced by the vaccines was approximately equal, regardless of which vaccine or method of immunization was used. Thus, live infection produced a more effective, broader immunity than did the use of inactivated virus vaccines.
在雪貂身上研究了甲型流感病毒香港/1/68株抗体与英格兰/42/72株抗体之间交叉反应所产生的免疫程度。通过活病毒感染或接种灭活病毒疫苗的方式用这些病毒对雪貂进行免疫。疫苗与弗氏不完全佐剂一起使用，或者给先前感染过甲型流感病毒PR/8/34的雪貂接种。经过这些免疫后，尽管与另一种病毒株的交叉反应程度各不相同，但所有动物都产生了与免疫病毒相似滴度的血清血凝抑制（HI）抗体。免疫后，用一种类似英格兰/42/72株的病毒感染这些动物，并测定它们的免疫程度。结果发现，免疫程度最高的是先前感染过同源英格兰/42/72病毒的雪貂。先前感染过香港/68病毒的动物对英格兰/42/72感染也表现出一定程度的免疫，且这种免疫程度高于接种灭活病毒疫苗的动物。无论使用哪种疫苗或免疫方法，疫苗所产生的免疫效果大致相同。因此，活病毒感染比使用灭活病毒疫苗产生的免疫更有效、范围更广。
